BRD-K70714754_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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58 genes differentially expressed following the BRD-K70714754_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
COLEC12 collectin sub-family member 12
DDIT4 DNA-damage-inducible transcript 4
FN1 fibronectin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GLUL glutamate-ammonia ligase
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
MT1E metallothionein 1E
NEB nebulin
NUPR1 nuclear protein, transcriptional regulator, 1
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
TAGLN transgelin
TMSB15A thymosin beta 15a
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPSAB1 tryptase alpha/beta 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3

decreased expression

Symbol Name
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ASCL1 achaete-scute family bHLH transcription factor 1
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
H2AFX H2A histone family, member X
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
KIF2C kinesin family member 2C
LAPTM4B lysosomal protein transmembrane 4 beta
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MBP myelin basic protein
MET MET proto-oncogene, receptor tyrosine kinase
MKI67 marker of proliferation Ki-67
NBN nibrin
NOLC1 nucleolar and coiled-body phosphoprotein 1
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
PUF60 poly-U binding splicing factor 60KDa
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1