BRD-K70642949_GSK-2334470_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K70642949_GSK-2334470_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
ASMTL acetylserotonin O-methyltransferase-like
CLIC5 chloride intracellular channel 5
CLSTN1 calsyntenin 1
CTGF connective tissue growth factor
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR1 early growth response 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GPATCH8 G patch domain containing 8
GPER1 G protein-coupled estrogen receptor 1
GREM1 gremlin 1, DAN family BMP antagonist
HSPA2 heat shock 70kDa protein 2
IGFBP7 insulin-like growth factor binding protein 7
KDM5D lysine (K)-specific demethylase 5D
KIF5C kinesin family member 5C
KRT19 keratin 19, type I
LXN latexin
NET1 neuroepithelial cell transforming 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
RBKS ribokinase
RCAN1 regulator of calcineurin 1
S100P S100 calcium binding protein P
SRPX sushi-repeat containing protein, X-linked
TCTA T-cell leukemia translocation altered
THBS1 thrombospondin 1
TMC5 transmembrane channel-like 5
UGCG UDP-glucose ceramide glucosyltransferase
VAV3 vav 3 guanine nucleotide exchange factor
VNN1 vanin 1
WRB tryptophan rich basic protein
XYLT1 xylosyltransferase I
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADM adrenomedullin
AK4 adenylate kinase 4
CALR calreticulin
CD53 CD53 molecule
CSTA cystatin A (stefin A)
CTSC cathepsin C
CYB5A cytochrome b5 type A (microsomal)
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
FAM13A family with sequence similarity 13, member A
HK2 hexokinase 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IPO13 importin 13
IQGAP1 IQ motif containing GTPase activating protein 1
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LTB lymphotoxin beta (TNF superfamily, member 3)
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEFH neurofilament, heavy polypeptide
NLRP2 NLR family, pyrin domain containing 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RGS1 regulator of G-protein signaling 1
RPS11 ribosomal protein S11
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFTPB surfactant protein B
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SUB1 SUB1 homolog (S. cerevisiae)
TMEM45A transmembrane protein 45A
TNIK TRAF2 and NCK interacting kinase
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon