BRD-K70642949_GSK-2334470_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

64 genes differentially expressed following the BRD-K70642949_GSK-2334470_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADGRG2 adhesion G protein-coupled receptor G2
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
C2CD2 C2 calcium-dependent domain containing 2
CCR7 chemokine (C-C motif) receptor 7
CREB1 cAMP responsive element binding protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EVI2A ecotropic viral integration site 2A
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
KCNK1 potassium channel, two pore domain subfamily K, member 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP10 matrix metallopeptidase 10
MUC4 mucin 4, cell surface associated
NRIP1 nuclear receptor interacting protein 1
PAPD7 PAP associated domain containing 7
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSCA prostate stem cell antigen
PXMP2 peroxisomal membrane protein 2, 22kDa
RTN1 reticulon 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC38A1 solute carrier family 38, member 1
SMAD3 SMAD family member 3
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBI transforming growth factor, beta-induced, 68kDa
TMPRSS3 transmembrane protease, serine 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADGRL2 adhesion G protein-coupled receptor L2
ALDOA aldolase A, fructose-bisphosphate
APOE apolipoprotein E
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL3A1 collagen, type III, alpha 1
COL9A3 collagen, type IX, alpha 3
CRYAB crystallin, alpha B
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
HSPB8 heat shock 22kDa protein 8
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KAT6B K(lysine) acetyltransferase 6B
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MALL mal, T-cell differentiation protein-like
MTCL1 microtubule crosslinking factor 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
SEPP1 selenoprotein P, plasma, 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
TBX2 T-box 2
TYRP1 tyrosinase-related protein 1
VDAC1 voltage-dependent anion channel 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)