BRD-K70642949_GSK-2334470_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K70642949_GSK-2334470_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
AGR2 anterior gradient 2
AGTR1 angiotensin II receptor, type 1
AQP3 aquaporin 3 (Gill blood group)
BMP7 bone morphogenetic protein 7
C8ORF4 chromosome 8 open reading frame 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHGB chromogranin B
COL4A5 collagen, type IV, alpha 5
CPVL carboxypeptidase, vitellogenic-like
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DLC1 DLC1 Rho GTPase activating protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPCAM epithelial cell adhesion molecule
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FOLR1 folate receptor 1 (adult)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HOPX HOP homeobox
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICAM2 intercellular adhesion molecule 2
IL6ST interleukin 6 signal transducer
ITGA6 integrin, alpha 6
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LACTB2 lactamase, beta 2
LAMP5 lysosomal-associated membrane protein family, member 5
LXN latexin
MARCKSL1 MARCKS-like 1
MAST4 microtubule associated serine/threonine kinase family member 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MMP7 matrix metallopeptidase 7
MYO6 myosin VI
NTS neurotensin
PLAT plasminogen activator, tissue
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
QPCT glutaminyl-peptide cyclotransferase
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
SELL selectin L
TBC1D4 TBC1 domain family, member 4
TEX10 testis expressed 10
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TRAF5 TNF receptor-associated factor 5
TSPAN13 tetraspanin 13

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CDK14 cyclin-dependent kinase 14
CEP55 centrosomal protein 55kDa
CFH complement factor H
COL6A1 collagen, type VI, alpha 1
COL8A2 collagen, type VIII, alpha 2
CPE carboxypeptidase E
CTBP2 C-terminal binding protein 2
CXCL9 chemokine (C-X-C motif) ligand 9
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTRA1 HtrA serine peptidase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP6 insulin-like growth factor binding protein 6
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
MEIS2 Meis homeobox 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP2 matrix metallopeptidase 2
NDRG1 N-myc downstream regulated 1
NIT1 nitrilase 1
NKX3-1 NK3 homeobox 1
PAPD7 PAP associated domain containing 7
PMM2 phosphomannomutase 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHB Src homology 2 domain containing adaptor protein B
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX7 sorting nexin 7
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STAR steroidogenic acute regulatory protein
STS steroid sulfatase (microsomal), isozyme S
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TM9SF3 transmembrane 9 superfamily member 3
TMEM176B transmembrane protein 176B
TYMP thymidine phosphorylase
VDAC1 voltage-dependent anion channel 1
ZNF395 zinc finger protein 395