BRD-K70642949_GSK-2334470_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K70642949_GSK-2334470_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
CDC42 cell division cycle 42
COL4A5 collagen, type IV, alpha 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP2 dual specificity phosphatase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELAVL1 ELAV like RNA binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHB2 EPH receptor B2
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
ICAM1 intercellular adhesion molecule 1
KDM5D lysine (K)-specific demethylase 5D
LTBP1 latent transforming growth factor beta binding protein 1
PFKL phosphofructokinase, liver
UGCG UDP-glucose ceramide glucosyltransferase
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
ANPEP alanyl (membrane) aminopeptidase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C1ORF115 chromosome 1 open reading frame 115
CFI complement factor I
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCN decorin
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
ENAH enabled homolog (Drosophila)
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GJA1 gap junction protein, alpha 1, 43kDa
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGB2 high mobility group box 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IPO13 importin 13
KCTD12 potassium channel tetramerization domain containing 12
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP2 matrix metallopeptidase 2
NDRG1 N-myc downstream regulated 1
NKG7 natural killer cell granule protein 7
NRIP1 nuclear receptor interacting protein 1
PDGFC platelet derived growth factor C
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAR steroidogenic acute regulatory protein
TLR4 toll-like receptor 4
TMEM45A transmembrane protein 45A
UGDH UDP-glucose 6-dehydrogenase
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395