BRD-K70577657_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K70577657_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT9 acyl-CoA thioesterase 9
ADM adrenomedullin
ARG2 arginase 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CD59 CD59 molecule, complement regulatory protein
CDK17 cyclin-dependent kinase 17
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY1 cryptochrome circadian clock 1
CSRP2 cysteine and glycine-rich protein 2
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DIDO1 death inducer-obliterator 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FBLN1 fibulin 1
FEM1B fem-1 homolog b (C. elegans)
FRZB frizzled-related protein
GREM1 gremlin 1, DAN family BMP antagonist
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KIAA0368 KIAA0368
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
LEF1 lymphoid enhancer-binding factor 1
LGALS2 lectin, galactoside-binding, soluble, 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
MYLK myosin light chain kinase
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
PAM peptidylglycine alpha-amidating monooxygenase
PAPOLA poly(A) polymerase alpha
PDGFA platelet-derived growth factor alpha polypeptide
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PRDX6 peroxiredoxin 6
PSAP prosaposin
QDPR quinoid dihydropteridine reductase
RCAN1 regulator of calcineurin 1
RNF11 ring finger protein 11
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN1 reticulon 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SELENBP1 selenium binding protein 1
SFN stratifin
SST somatostatin
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TMPO thymopoietin
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)

decreased expression

Symbol Name
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP15 Rho GTPase activating protein 15
ATP8B4 ATPase, class I, type 8B, member 4
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLNK B-cell linker
BRCA1 breast cancer 1, early onset
CAV2 caveolin 2
CDC25B cell division cycle 25B
CDK12 cyclin-dependent kinase 12
CFB complement factor B
CLDN10 claudin 10
CLGN calmegin
CNN3 calponin 3, acidic
CP ceruloplasmin (ferroxidase)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
DHRS2 dehydrogenase/reductase (SDR family) member 2
FAM208A family with sequence similarity 208, member A
FAM57A family with sequence similarity 57, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP4 insulin-like growth factor binding protein 4
INTS3 integrator complex subunit 3
JADE2 jade family PHD finger 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRCC1 lysine-rich coiled-coil 1
KRT7 keratin 7, type II
KYNU kynureninase
LGALS4 lectin, galactoside-binding, soluble, 4
LYST lysosomal trafficking regulator
MKKS McKusick-Kaufman syndrome
MT1X metallothionein 1X
MTA1 metastasis associated 1
MTDH metadherin
MYB v-myb avian myeloblastosis viral oncogene homolog
NFIB nuclear factor I/B
NID2 nidogen 2 (osteonidogen)
OPN3 opsin 3
ORC3 origin recognition complex, subunit 3
OXLD1 oxidoreductase-like domain containing 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PEG3 paternally expressed 3
PLCB4 phospholipase C, beta 4
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PXDN peroxidasin
RAB29 RAB29, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAD51C RAD51 paralog C
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SCN3A sodium channel, voltage gated, type III alpha subunit
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SPDEF SAM pointed domain containing ETS transcription factor
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAR steroidogenic acute regulatory protein
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFPI2 tissue factor pathway inhibitor 2
TMEM5 transmembrane protein 5
TOR1A torsin family 1, member A (torsin A)
TOX3 TOX high mobility group box family member 3
TPBG trophoblast glycoprotein
TPD52 tumor protein D52
TRAPPC12 trafficking protein particle complex 12
TRIP6 thyroid hormone receptor interactor 6
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
UBE3C ubiquitin protein ligase E3C
VIM vimentin