BRD-K70549064_EI-156_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

364 genes differentially expressed following the BRD-K70549064_EI-156_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL4 adhesion G protein-coupled receptor L4
ANXA4 annexin A4
ANXA9 annexin A9
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBS cystathionine-beta-synthase
CCND2 cyclin D2
CD38 CD38 molecule
CD52 CD52 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CECR1 cat eye syndrome chromosome region, candidate 1
CHN2 chimerin 2
CLC Charcot-Leyden crystal galectin
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
CYBRD1 cytochrome b reductase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCHS1 dachsous cadherin-related 1
DCN decorin
DDR2 discoidin domain receptor tyrosine kinase 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
EPYC epiphycan
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLT1 fms-related tyrosine kinase 1
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GLT8D2 glycosyltransferase 8 domain containing 2
HBE1 hemoglobin, epsilon 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN4 high mobility group nucleosomal binding domain 4
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INA internexin neuronal intermediate filament protein, alpha
ISYNA1 inositol-3-phosphate synthase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2C integral membrane protein 2C
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
LUM lumican
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP9 matrix metallopeptidase 9
MSLN mesothelin
MUC16 mucin 16, cell surface associated
NREP neuronal regeneration related protein
NTAN1 N-terminal asparagine amidase
ORM1 orosomucoid 1
PBX3 pre-B-cell leukemia homeobox 3
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PLVAP plasmalemma vesicle associated protein
POSTN periostin, osteoblast specific factor
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCI protein kinase C, iota
PRSS16 protease, serine, 16 (thymus)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SEPT2 septin 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TEK TEK tyrosine kinase, endothelial
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMSB15A thymosin beta 15a
TPGS2 tubulin polyglutamylase complex subunit 2
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
UGP2 UDP-glucose pyrophosphorylase 2
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AFF1 AF4/FMR2 family, member 1
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMACR alpha-methylacyl-CoA racemase
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ARF6 ADP-ribosylation factor 6
ARID1A AT rich interactive domain 1A (SWI-like)
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIK BCL2-interacting killer (apoptosis-inducing)
BRPF1 bromodomain and PHD finger containing, 1
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF169 chromosome 14 open reading frame 169
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CST1 cystatin SN
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMBP dynamin binding protein
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFHD2 EF-hand domain family, member D2
EHD1 EH-domain containing 1
EIF4B eukaryotic translation initiation factor 4B
EIF5 eukaryotic translation initiation factor 5
EMP3 epithelial membrane protein 3
EPHA2 EPH receptor A2
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADD Fas (TNFRSF6)-associated via death domain
FAM46A family with sequence similarity 46, member A
FAM98A family with sequence similarity 98, member A
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GMDS GDP-mannose 4,6-dehydratase
GPATCH8 G patch domain containing 8
GRWD1 glutamate-rich WD repeat containing 1
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HOXC6 homeobox C6
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITGA6 integrin, alpha 6
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KAT6B K(lysine) acetyltransferase 6B
KAT7 K(lysine) acetyltransferase 7
KCTD5 potassium channel tetramerization domain containing 5
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIAA1033 KIAA1033
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MED13 mediator complex subunit 13
MEPCE methylphosphate capping enzyme
MKNK2 MAP kinase interacting serine/threonine kinase 2
MRPS2 mitochondrial ribosomal protein S2
MRPS30 mitochondrial ribosomal protein S30
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NMB neuromedin B
NOP56 NOP56 ribonucleoprotein
NOSIP nitric oxide synthase interacting protein
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PDLIM5 PDZ and LIM domain 5
PEBP1 phosphatidylethanolamine binding protein 1
PFKP phosphofructokinase, platelet
PHF20 PHD finger protein 20
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PNMA1 paraneoplastic Ma antigen 1
PPIF peptidylprolyl isomerase F
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES prostaglandin E synthase
RAB22A RAB22A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RBM12 RNA binding motif protein 12
RBM14 RNA binding motif protein 14
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIN2 Ras and Rab interactor 2
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPP25 ribonuclease P/MRP 25kDa subunit
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SACS sacsin molecular chaperone
SAR1A secretion associated, Ras related GTPase 1A
SCAF8 SR-related CTD-associated factor 8
SECISBP2L SECIS binding protein 2-like
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SETD5 SET domain containing 5
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SLC25A44 solute carrier family 25, member 44
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMG8 SMG8 nonsense mediated mRNA decay factor
SNRK SNF related kinase
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SPTBN1 spectrin, beta, non-erythrocytic 1
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC1 transforming, acidic coiled-coil containing protein 1
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFB2M transcription factor B2, mitochondrial
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TICAM1 toll-like receptor adaptor molecule 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TLE3 transducin-like enhancer of split 3
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL1 TSPY-like 1
TUBB2A tubulin, beta 2A class IIa
TXLNA taxilin alpha
UBAP2L ubiquitin associated protein 2-like
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WDR6 WD repeat domain 6
WDR82 WD repeat domain 82
WIPF2 WAS/WASL interacting protein family, member 2
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZC3H4 zinc finger CCCH-type containing 4
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZNF207 zinc finger protein 207
ZNF330 zinc finger protein 330