BRD-K70511574_sunitinib_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K70511574_sunitinib_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
E2F2 E2F transcription factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP4 fatty acid binding protein 4, adipocyte
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HIST1H2BG histone cluster 1, H2bg
ITGA6 integrin, alpha 6
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MAP1B microtubule-associated protein 1B
MT1M metallothionein 1M
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLAC8 placenta-specific 8
PLSCR3 phospholipid scramblase 3
PTPRC protein tyrosine phosphatase, receptor type, C
RPS11 ribosomal protein S11
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC38A1 solute carrier family 38, member 1
SPRR1A small proline-rich protein 1A
SRPX sushi-repeat containing protein, X-linked
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TMEM97 transmembrane protein 97
VAMP8 vesicle-associated membrane protein 8
VCAN versican
WASF3 WAS protein family, member 3

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
APOC1 apolipoprotein C-I
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CALR calreticulin
CCL20 chemokine (C-C motif) ligand 20
CD200 CD200 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CGRRF1 cell growth regulator with ring finger domain 1
COL1A2 collagen, type I, alpha 2
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPQ carboxypeptidase Q
DMD dystrophin
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DOCK4 dedicator of cytokinesis 4
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
GBAS glioblastoma amplified sequence
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GUSBP3 glucuronidase, beta pseudogene 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LGALS3 lectin, galactoside-binding, soluble, 3
LTF lactotransferrin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MERTK MER proto-oncogene, tyrosine kinase
MXRA7 matrix-remodelling associated 7
NR1H2 nuclear receptor subfamily 1, group H, member 2
PCP4 Purkinje cell protein 4
PDLIM1 PDZ and LIM domain 1
PTN pleiotrophin
RNASE4 ribonuclease, RNase A family, 4
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAR steroidogenic acute regulatory protein
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TCTN1 tectonic family member 1
TLR4 toll-like receptor 4
TREM1 triggering receptor expressed on myeloid cells 1
WFDC2 WAP four-disulfide core domain 2
WT1 Wilms tumor 1