BRD-K70511574_sunitinib_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K70511574_sunitinib_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANOS1 anosmin 1
ANXA3 annexin A3
ARL4A ADP-ribosylation factor-like 4A
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BMP7 bone morphogenetic protein 7
CAV2 caveolin 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLTB clathrin, light chain B
COBL cordon-bleu WH2 repeat protein
COL18A1 collagen, type XVIII, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DCLK1 doublecortin-like kinase 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FDX1 ferredoxin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPB8 heat shock 22kDa protein 8
KDM4B lysine (K)-specific demethylase 4B
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT18 keratin 18, type I
LMO4 LIM domain only 4
LTF lactotransferrin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYOF myoferlin
NELL2 NEL-like 2 (chicken)
NTS neurotensin
PAWR PRKC, apoptosis, WT1, regulator
PGC progastricsin (pepsinogen C)
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PPIG peptidylprolyl isomerase G (cyclophilin G)
PSRC1 proline/serine-rich coiled-coil 1
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RBP1 retinol binding protein 1, cellular
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS10 regulator of G-protein signaling 10
SCD5 stearoyl-CoA desaturase 5
SDC2 syndecan 2
SEC62 SEC62 homolog (S. cerevisiae)
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STEAP3 STEAP family member 3, metalloreductase
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TIMP1 TIMP metallopeptidase inhibitor 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRAC T cell receptor alpha constant
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
CALD1 caldesmon 1
CCNE2 cyclin E2
CCNG2 cyclin G2
CD200 CD200 molecule
CD58 CD58 molecule
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CHEK2 checkpoint kinase 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CTSK cathepsin K
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPT dermatopontin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
FABP1 fatty acid binding protein 1, liver
FAR2 fatty acyl CoA reductase 2
FGL2 fibrinogen-like 2
FN1 fibronectin 1
FOXG1 forkhead box G1
FRZB frizzled-related protein
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAS1 growth arrest-specific 1
GBP1 guanylate binding protein 1, interferon-inducible
GPX2 glutathione peroxidase 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL32 interleukin 32
KRT23 keratin 23, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100505650 uncharacterized LOC100505650
MANSC1 MANSC domain containing 1
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MMD monocyte to macrophage differentiation-associated
MSH6 mutS homolog 6
NGRN neugrin, neurite outgrowth associated
NOV nephroblastoma overexpressed
NUSAP1 nucleolar and spindle associated protein 1
PEG10 paternally expressed 10
RAD51AP1 RAD51 associated protein 1
RGS2 regulator of G-protein signaling 2
RNMT RNA (guanine-7-) methyltransferase
RPN1 ribophorin I
RRM2 ribonucleotide reductase M2
SEPP1 selenoprotein P, plasma, 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMP3 TIMP metallopeptidase inhibitor 3
TLE4 transducin-like enhancer of split 4
TMEM106C transmembrane protein 106C
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TPM2 tropomyosin 2 (beta)
TRIB1 tribbles pseudokinase 1
TUG1 taurine up-regulated 1 (non-protein coding)
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
VIM vimentin
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
ZWINT ZW10 interacting kinetochore protein