BRD-K70511574_sunitinib_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K70511574_sunitinib_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AK1 adenylate kinase 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BAG2 BCL2-associated athanogene 2
BAX BCL2-associated X protein
CCNE2 cyclin E2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLGN calmegin
COL4A5 collagen, type IV, alpha 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
ELAVL1 ELAV like RNA binding protein 1
FDXR ferredoxin reductase
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIST1H2BK histone cluster 1, H2bk
HLA-B major histocompatibility complex, class I, B
IER3 immediate early response 3
ISCU iron-sulfur cluster assembly enzyme
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LAPTM5 lysosomal protein transmembrane 5
MAP1B microtubule-associated protein 1B
PLK2 polo-like kinase 2
POSTN periostin, osteoblast specific factor
RBMS1 RNA binding motif, single stranded interacting protein 1
RGS1 regulator of G-protein signaling 1
RPS27L ribosomal protein S27-like
SIRT3 sirtuin 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP1 TIMP metallopeptidase inhibitor 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNIK TRAF2 and NCK interacting kinase
VAMP8 vesicle-associated membrane protein 8
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIRF adipogenesis regulatory factor
AK4 adenylate kinase 4
AQP1 aquaporin 1 (Colton blood group)
ASPH aspartate beta-hydroxylase
BEX1 brain expressed, X-linked 1
C10ORF10 chromosome 10 open reading frame 10
CALD1 caldesmon 1
CDK1 cyclin-dependent kinase 1
CDO1 cysteine dioxygenase type 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CRIP1 cysteine-rich protein 1 (intestinal)
CTBP2 C-terminal binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYBB cytochrome b-245, beta polypeptide
DIO1 deiodinase, iodothyronine, type I
DPYSL2 dihydropyrimidinase-like 2
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGFR epidermal growth factor receptor
FHL1 four and a half LIM domains 1
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HMGA2 high mobility group AT-hook 2
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1R1 interleukin 1 receptor, type I
IPO13 importin 13
KLK5 kallikrein-related peptidase 5
KLK7 kallikrein-related peptidase 7
KRT14 keratin 14, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NOV nephroblastoma overexpressed
NRIP1 nuclear receptor interacting protein 1
NUSAP1 nucleolar and spindle associated protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRL platelet-derived growth factor receptor-like
PECR peroxisomal trans-2-enoyl-CoA reductase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
PON3 paraoxonase 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE4 ribonuclease, RNase A family, 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A4 solute carrier family 16, member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMPRSS3 transmembrane protease, serine 3
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
VDAC1 voltage-dependent anion channel 1
WDR7 WD repeat domain 7
ZBED2 zinc finger, BED-type containing 2
ZNF395 zinc finger protein 395
ZWINT ZW10 interacting kinetochore protein