BRD-K70511574_sunitinib_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K70511574_sunitinib_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C2CD5 C2 calcium-dependent domain containing 5
CADM1 cell adhesion molecule 1
CALML5 calmodulin-like 5
CCL19 chemokine (C-C motif) ligand 19
CDC20 cell division cycle 20
CHN1 chimerin 1
CLDN8 claudin 8
COCH cochlin
COL11A1 collagen, type XI, alpha 1
CST1 cystatin SN
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
GPM6B glycoprotein M6B
GRIA2 glutamate receptor, ionotropic, AMPA 2
HHEX hematopoietically expressed homeobox
HSPA2 heat shock 70kDa protein 2
KIF14 kinesin family member 14
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PLLP plasmolipin
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PTPRC protein tyrosine phosphatase, receptor type, C
PTX3 pentraxin 3, long
RAB4A RAB4A, member RAS oncogene family
RGS1 regulator of G-protein signaling 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A2 S100 calcium binding protein A2
SDC2 syndecan 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TARP TCR gamma alternate reading frame protein
TES testin LIM domain protein
TGM2 transglutaminase 2
TNC tenascin C
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX6 armadillo repeat containing, X-linked 6
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CD24 CD24 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CELF2 CUGBP, Elav-like family member 2
ECM1 extracellular matrix protein 1
EZR ezrin
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FLRT3 fibronectin leucine rich transmembrane protein 3
FMO2 flavin containing monooxygenase 2 (non-functional)
GPX1 glutathione peroxidase 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H4C histone cluster 1, H4c
IGFBP5 insulin-like growth factor binding protein 5
KLK12 kallikrein-related peptidase 12
KRT20 keratin 20, type I
KRT23 keratin 23, type I
LPCAT1 lysophosphatidylcholine acyltransferase 1
MME membrane metallo-endopeptidase
MTCL1 microtubule crosslinking factor 1
MZB1 marginal zone B and B1 cell-specific protein
PLAGL1 pleiomorphic adenoma gene-like 1
PLBD1 phospholipase B domain containing 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PRSS2 protease, serine, 2 (trypsin 2)
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
RHCG Rh family, C glycoprotein
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPB surfactant protein B
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR3 small proline-rich protein 3
SRRM2 serine/arginine repetitive matrix 2
ZBED2 zinc finger, BED-type containing 2