BRD-K70511574_sunitinib_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K70511574_sunitinib_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCND1 cyclin D1
CTSW cathepsin W
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
EDNRB endothelin receptor type B
GDF15 growth differentiation factor 15
GREM1 gremlin 1, DAN family BMP antagonist
GSPT1 G1 to S phase transition 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGKV4-1 immunoglobulin kappa variable 4-1
INSM1 insulinoma-associated 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAST2 microtubule associated serine/threonine kinase 2
NNMT nicotinamide N-methyltransferase
PCSK1 proprotein convertase subtilisin/kexin type 1
PODXL podocalyxin-like
RAB21 RAB21, member RAS oncogene family
SESN1 sestrin 1
SRGN serglycin
SRRM2 serine/arginine repetitive matrix 2
TESK1 testis-specific kinase 1
ZMAT3 zinc finger, matrin-type 3
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
CADM1 cell adhesion molecule 1
CD52 CD52 molecule
CFH complement factor H
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL1A2 collagen, type I, alpha 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FBN2 fibrillin 2
FOXG1 forkhead box G1
GPX2 glutathione peroxidase 2
LMO4 LIM domain only 4
LYZ lysozyme
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MRPS16 mitochondrial ribosomal protein S16
MSMB microseminoprotein, beta-
NQO1 NAD(P)H dehydrogenase, quinone 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PSD3 pleckstrin and Sec7 domain containing 3
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon