BRD-K70415218_2-(4-(2-butoxy-5-chlorophenylamino)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-ylamino)ethanol wh-gc-round5-67_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K70415218_2-(4-(2-butoxy-5-chlorophenylamino)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-ylamino)ethanol wh-gc-round5-67_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA3 annexin A3
AREG amphiregulin
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CD52 CD52 molecule
CD9 CD9 molecule
CLC Charcot-Leyden crystal galectin
CREB1 cAMP responsive element binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP6 dual specificity phosphatase 6
EREG epiregulin
EVI2A ecotropic viral integration site 2A
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GFOD1 glucose-fructose oxidoreductase domain containing 1
GSTO1 glutathione S-transferase omega 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
KLF4 Kruppel-like factor 4 (gut)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAT2B methionine adenosyltransferase II, beta
MREG melanoregulin
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
PDLIM4 PDZ and LIM domain 4
PLAT plasminogen activator, tissue
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PSD3 pleckstrin and Sec7 domain containing 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC38A1 solute carrier family 38, member 1
SLPI secretory leukocyte peptidase inhibitor
SPAG16 sperm associated antigen 16
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
WNT5A wingless-type MMTV integration site family, member 5A
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
CA12 carbonic anhydrase XII
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CLU clusterin
COL3A1 collagen, type III, alpha 1
CYR61 cysteine-rich, angiogenic inducer, 61
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GOLGA4 golgin A4
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MATN2 matrilin 2
PLK2 polo-like kinase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
S100A10 S100 calcium binding protein A10
SPRED2 sprouty-related, EVH1 domain containing 2
VAV3 vav 3 guanine nucleotide exchange factor