BRD-K70401845_erlotinib_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K70401845_erlotinib_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ASCL1 achaete-scute family bHLH transcription factor 1
BID BH3 interacting domain death agonist
BPIFA1 BPI fold containing family A, member 1
CCNG2 cyclin G2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
E2F2 E2F transcription factor 2
EFNA1 ephrin-A1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
F13A1 coagulation factor XIII, A1 polypeptide
FGA fibrinogen alpha chain
GLUL glutamate-ammonia ligase
GOLM1 golgi membrane protein 1
HMOX1 heme oxygenase 1
KLHL24 kelch-like family member 24
LCN2 lipocalin 2
LITAF lipopolysaccharide-induced TNF factor
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PPAP2A phosphatidic acid phosphatase type 2A
RAB11FIP1 RAB11 family interacting protein 1 (class I)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SIDT2 SID1 transmembrane family, member 2
SPON2 spondin 2, extracellular matrix protein
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TARP TCR gamma alternate reading frame protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM135 transmembrane protein 135
TTC39A tetratricopeptide repeat domain 39A
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AURKA aurora kinase A
BTG3 BTG family, member 3
CCND1 cyclin D1
CD69 CD69 molecule
CLEC2B C-type lectin domain family 2, member B
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
EMX2 empty spiracles homeobox 2
ETV1 ets variant 1
FAM46A family with sequence similarity 46, member A
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNAS GNAS complex locus
GPER1 G protein-coupled estrogen receptor 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HK2 hexokinase 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IL13RA2 interleukin 13 receptor, alpha 2
KIF14 kinesin family member 14
LYPD1 LY6/PLAUR domain containing 1
MACF1 microtubule-actin crosslinking factor 1
MGLL monoglyceride lipase
MTERF3 mitochondrial transcription termination factor 3
NPTX2 neuronal pentraxin II
PLAT plasminogen activator, tissue
PPARG peroxisome proliferator-activated receptor gamma
S100A2 S100 calcium binding protein A2
SEH1L SEH1-like (S. cerevisiae)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPRY2 sprouty homolog 2 (Drosophila)
SRSF2 serine/arginine-rich splicing factor 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TLR4 toll-like receptor 4
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing