BRD-K70161581_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K70161581_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BLCAP bladder cancer associated protein
BMP2 bone morphogenetic protein 2
BMP7 bone morphogenetic protein 7
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA9 carbonic anhydrase IX
CD69 CD69 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CXORF57 chromosome X open reading frame 57
DARS aspartyl-tRNA synthetase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
EDN3 endothelin 3
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
F11R F11 receptor
FAM134B family with sequence similarity 134, member B
FAM162A family with sequence similarity 162, member A
FAS Fas cell surface death receptor
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBE1 glucan (1,4-alpha-), branching enzyme 1
GPI glucose-6-phosphate isomerase
GRAMD3 GRAM domain containing 3
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLX H2.0-like homeobox
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
INSIG2 insulin induced gene 2
ISG20 interferon stimulated exonuclease gene 20kDa
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
LGALS8 lectin, galactoside-binding, soluble, 8
LHX2 LIM homeobox 2
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LRP4 low density lipoprotein receptor-related protein 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MMP12 matrix metallopeptidase 12
MT1M metallothionein 1M
MT1X metallothionein 1X
MT3 metallothionein 3
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NREP neuronal regeneration related protein
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAM peptidylglycine alpha-amidating monooxygenase
PCLO piccolo presynaptic cytomatrix protein
PDE4DIP phosphodiesterase 4D interacting protein
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PKM pyruvate kinase, muscle
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RGS1 regulator of G-protein signaling 1
RNASET2 ribonuclease T2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPAG4 sperm associated antigen 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC1 stanniocalcin 1
SYBU syntabulin (syntaxin-interacting)
TF transferrin
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNIP1 TNFAIP3 interacting protein 1
TPI1 triosephosphate isomerase 1
TRIM22 tripartite motif containing 22
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
ZMAT3 zinc finger, matrin-type 3
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ANXA2 annexin A2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CAPN2 calpain 2, (m/II) large subunit
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CIT citron rho-interacting serine/threonine kinase
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ESR1 estrogen receptor 1
FOLR1 folate receptor 1 (adult)
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GTSE1 G-2 and S-phase expressed 1
HSPA1A heat shock 70kDa protein 1A
IGFBP4 insulin-like growth factor binding protein 4
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JADE2 jade family PHD finger 2
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MGP matrix Gla protein
NEK2 NIMA-related kinase 2
NPY1R neuropeptide Y receptor Y1
PBX1 pre-B-cell leukemia homeobox 1
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
TACC3 transforming, acidic coiled-coil containing protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
ZBTB18 zinc finger and BTB domain containing 18