BRD-K69932463_AZD-8055_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K69932463_AZD-8055_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ANXA1 annexin A1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APLP2 amyloid beta (A4) precursor-like protein 2
CD36 CD36 molecule (thrombospondin receptor)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
CYBA cytochrome b-245, alpha polypeptide
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DMTF1 cyclin D binding myb-like transcription factor 1
DPYSL2 dihydropyrimidinase-like 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
GDF15 growth differentiation factor 15
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX4 glutathione peroxidase 4
HCK HCK proto-oncogene, Src family tyrosine kinase
HEATR1 HEAT repeat containing 1
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST3H2A histone cluster 3, H2a
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNMT histamine N-methyltransferase
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS2 insulin receptor substrate 2
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
LBP lipopolysaccharide binding protein
LGALS1 lectin, galactoside-binding, soluble, 1
MET MET proto-oncogene, receptor tyrosine kinase
NAV2 neuron navigator 2
PLSCR4 phospholipid scramblase 4
PROS1 protein S (alpha)
PSAP prosaposin
PTGES prostaglandin E synthase
PTK2 protein tyrosine kinase 2
RNMT RNA (guanine-7-) methyltransferase
SCAND1 SCAN domain containing 1
SDCBP syndecan binding protein (syntenin)
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SYNM synemin, intermediate filament protein
TIMP1 TIMP metallopeptidase inhibitor 1
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1
TSPAN6 tetraspanin 6
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor
ZNF318 zinc finger protein 318

decreased expression

Symbol Name
BHLHE41 basic helix-loop-helix family, member e41
BTG3 BTG family, member 3
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDK2 cyclin-dependent kinase 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPU centromere protein U
CNN3 calponin 3, acidic
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CXCL8 chemokine (C-X-C motif) ligand 8
EPHA3 EPH receptor A3
FASTKD5 FAST kinase domains 5
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GJA1 gap junction protein, alpha 1, 43kDa
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
JMJD6 jumonji domain containing 6
KLF10 Kruppel-like factor 10
LEF1 lymphoid enhancer-binding factor 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NXT1 nuclear transport factor 2-like export factor 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
REEP5 receptor accessory protein 5
SI sucrase-isomaltase (alpha-glucosidase)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
TESK1 testis-specific kinase 1
TNIP1 TNFAIP3 interacting protein 1
TOX3 TOX high mobility group box family member 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
ZMIZ1 zinc finger, MIZ-type containing 1