BRD-K69932463_AZD-8055_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

182 genes differentially expressed following the BRD-K69932463_AZD-8055_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAM10 ADAM metallopeptidase domain 10
AKAP9 A kinase (PRKA) anchor protein 9
AMIGO2 adhesion molecule with Ig-like domain 2
ASMTL acetylserotonin O-methyltransferase-like
ATP9A ATPase, class II, type 9A
BHLHE41 basic helix-loop-helix family, member e41
C5AR1 complement component 5a receptor 1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK14 cyclin-dependent kinase 14
CDK19 cyclin-dependent kinase 19
CDK7 cyclin-dependent kinase 7
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CLDN10 claudin 10
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DUSP4 dual specificity phosphatase 4
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM63B family with sequence similarity 63, member B
FOXO3 forkhead box O3
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
GPR137B G protein-coupled receptor 137B
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IQGAP1 IQ motif containing GTPase activating protein 1
IRS1 insulin receptor substrate 1
KLHL24 kelch-like family member 24
LCN2 lipocalin 2
LRRC17 leucine rich repeat containing 17
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS1 Meis homeobox 1
MGLL monoglyceride lipase
MVP major vault protein
N4BP2L1 NEDD4 binding protein 2-like 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMI N-myc (and STAT) interactor
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RAB9A RAB9A, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS10 regulator of G-protein signaling 10
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SECISBP2L SECIS binding protein 2-like
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SP100 SP100 nuclear antigen
SPDEF SAM pointed domain containing ETS transcription factor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYF2 SYF2 pre-mRNA-splicing factor
SYNJ2 synaptojanin 2
TFPI2 tissue factor pathway inhibitor 2
TJP2 tight junction protein 2
TSC22D1 TSC22 domain family, member 1
VNN1 vanin 1
WASL Wiskott-Aldrich syndrome-like
WDR45 WD repeat domain 45
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF185 zinc finger protein 185 (LIM domain)
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
C20ORF24 chromosome 20 open reading frame 24
C3 complement component 3
CA2 carbonic anhydrase II
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A2 collagen, type I, alpha 2
COL4A6 collagen, type IV, alpha 6
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CYCS cytochrome c, somatic
DCK deoxycytidine kinase
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
E2F2 E2F transcription factor 2
EBP emopamil binding protein (sterol isomerase)
EIF4E eukaryotic translation initiation factor 4E
ELOVL6 ELOVL fatty acid elongase 6
FABP7 fatty acid binding protein 7, brain
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGF2 fibroblast growth factor 2 (basic)
FRZB frizzled-related protein
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLIPR1 GLI pathogenesis-related 1
GRB14 growth factor receptor-bound protein 14
H2AFZ H2A histone family, member Z
HACD2 3-hydroxyacyl-CoA dehydratase 2
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HRASLS HRAS-like suppressor
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP5 insulin-like growth factor binding protein 5
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LBR lamin B receptor
LUM lumican
MALT1 MALT1 paracaspase
MGP matrix Gla protein
MRPL3 mitochondrial ribosomal protein L3
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
MYLK myosin light chain kinase
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPY1R neuropeptide Y receptor Y1
PCCB propionyl CoA carboxylase, beta polypeptide
PCDH9 protocadherin 9
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE4D phosphodiesterase 4D, cAMP-specific
PGAM1 phosphoglycerate mutase 1 (brain)
PLK1 polo-like kinase 1
PLN phospholamban
PNP purine nucleoside phosphorylase
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTTG1 pituitary tumor-transforming 1
RAD51C RAD51 paralog C
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REEP1 receptor accessory protein 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCRG1 stimulator of chondrogenesis 1
SFN stratifin
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SORBS1 sorbin and SH3 domain containing 1
SPARCL1 SPARC-like 1 (hevin)
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SRPRB signal recognition particle receptor, B subunit
SRSF7 serine/arginine-rich splicing factor 7
SYNM synemin, intermediate filament protein
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM45A transmembrane protein 45A
TMEM97 transmembrane protein 97
TNC tenascin C
TPSAB1 tryptase alpha/beta 1
TRA2B transformer 2 beta homolog (Drosophila)
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
WDR61 WD repeat domain 61
ZWINT ZW10 interacting kinetochore protein