BRD-K69932463_AZD-8055_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-K69932463_AZD-8055_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASMTL acetylserotonin O-methyltransferase-like
BCL2L1 BCL2-like 1
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CAMLG calcium modulating ligand
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNA1 ephrin-A1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB3 erb-b2 receptor tyrosine kinase 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOXO3 forkhead box O3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GRB7 growth factor receptor-bound protein 7
HIST1H2AC histone cluster 1, H2ac
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5A lysine (K)-specific demethylase 5A
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAMB3 laminin, beta 3
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MLPH melanophilin
MVP major vault protein
MYOF myoferlin
MYRF myelin regulatory factor
NBPF10 neuroblastoma breakpoint family, member 10
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OBSL1 obscurin-like 1
PLAU plasminogen activator, urokinase
PLXNB2 plexin B2
PNMA2 paraneoplastic Ma antigen 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPL periplakin
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RRAD Ras-related associated with diabetes
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SECISBP2L SECIS binding protein 2-like
SFRP4 secreted frizzled-related protein 4
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPATA7 spermatogenesis associated 7
SPRED2 sprouty-related, EVH1 domain containing 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
SVIL supervillin
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNJ2 synaptojanin 2
TANK TRAF family member-associated NFKB activator
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TOB2 transducer of ERBB2, 2
WASL Wiskott-Aldrich syndrome-like
XIST X inactive specific transcript (non-protein coding)
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP1 aquaporin 1 (Colton blood group)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
CALR calreticulin
CCNA2 cyclin A2
CCND3 cyclin D3
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A2 collagen, type I, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CTPS1 CTP synthase 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
DCN decorin
EBP emopamil binding protein (sterol isomerase)
EDNRB endothelin receptor type B
EIF4E eukaryotic translation initiation factor 4E
FABP7 fatty acid binding protein 7, brain
FAS Fas cell surface death receptor
FBN2 fibrillin 2
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGF2 fibroblast growth factor 2 (basic)
FHL1 four and a half LIM domains 1
FOXG1 forkhead box G1
FRZB frizzled-related protein
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAL galanin/GMAP prepropeptide
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNAS GNAS complex locus
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB1 high mobility group box 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LBR lamin B receptor
LPL lipoprotein lipase
MALT1 MALT1 paracaspase
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MELK maternal embryonic leucine zipper kinase
MOXD1 monooxygenase, DBH-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PCDH9 protocadherin 9
PDZK1 PDZ domain containing 1
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SORBS1 sorbin and SH3 domain containing 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SRPRB signal recognition particle receptor, B subunit
STMN1 stathmin 1
TDO2 tryptophan 2,3-dioxygenase
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TMPO thymopoietin
TMX2 thioredoxin-related transmembrane protein 2
TNC tenascin C
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2S ubiquitin-conjugating enzyme E2S
VBP1 von Hippel-Lindau binding protein 1
WSB2 WD repeat and SOCS box containing 2
ZWINT ZW10 interacting kinetochore protein