BRD-K69932463_AZD-8055_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K69932463_AZD-8055_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BHLHE40 basic helix-loop-helix family, member e40
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD14 CD14 molecule
CD163 CD163 molecule
CD34 CD34 molecule
CD59 CD59 molecule, complement regulatory protein
CST3 cystatin C
CXCL5 chemokine (C-X-C motif) ligand 5
EPHB2 EPH receptor B2
FOS FBJ murine osteosarcoma viral oncogene homolog
GPX3 glutathione peroxidase 3
IFITM1 interferon induced transmembrane protein 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
KRT14 keratin 14, type I
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MET MET proto-oncogene, receptor tyrosine kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPIPB3 nuclear pore complex interacting protein family, member B3
P3H2 prolyl 3-hydroxylase 2
RBM47 RNA binding motif protein 47
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCYL3 SCY1-like 3 (S. cerevisiae)
STK26 serine/threonine protein kinase 26
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARG2 arginase 2
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
CBR3 carbonyl reductase 3
CD99 CD99 molecule
CDC25A cell division cycle 25A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
FA2H fatty acid 2-hydroxylase
FBLN5 fibulin 5
GCH1 GTP cyclohydrolase 1
GREM1 gremlin 1, DAN family BMP antagonist
HOXC10 homeobox C10
HOXC6 homeobox C6
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
LMO2 LIM domain only 2 (rhombotin-like 1)
NID1 nidogen 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PRPF4 pre-mRNA processing factor 4
PTPRO protein tyrosine phosphatase, receptor type, O
PTS 6-pyruvoyltetrahydropterin synthase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SPINK1 serine peptidase inhibitor, Kazal type 1
TSPAN8 tetraspanin 8
UQCRH ubiquinol-cytochrome c reductase hinge protein