BRD-K69932463_AZD-8055_MDAMB231_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K69932463_AZD-8055_MDAMB231_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMOTL2 angiomotin like 2
BICC1 BicC family RNA binding protein 1
CEP57 centrosomal protein 57kDa
CKB creatine kinase, brain
CTGF connective tissue growth factor
CTSE cathepsin E
CTSH cathepsin H
CXCL8 chemokine (C-X-C motif) ligand 8
ETV1 ets variant 1
FGFR4 fibroblast growth factor receptor 4
FNDC3B fibronectin type III domain containing 3B
HMOX1 heme oxygenase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IL18 interleukin 18
IL6 interleukin 6
ISLR immunoglobulin superfamily containing leucine-rich repeat
KLK10 kallikrein-related peptidase 10
LIMCH1 LIM and calponin homology domains 1
LIPG lipase, endothelial
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MSLN mesothelin
NARFL nuclear prelamin A recognition factor-like
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PLA2G16 phospholipase A2, group XVI
PSAP prosaposin
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFTPB surfactant protein B
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX4 SRY (sex determining region Y)-box 4
TSHR thyroid stimulating hormone receptor
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARL4A ADP-ribosylation factor-like 4A
BEX4 brain expressed, X-linked 4
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS2 dehydrogenase/reductase (SDR family) member 2
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGF13 fibroblast growth factor 13
FKBP1B FK506 binding protein 1B, 12.6 kDa
GPX7 glutathione peroxidase 7
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA2 heat shock 70kDa protein 2
IGHM immunoglobulin heavy constant mu
JMJD6 jumonji domain containing 6
KRAS Kirsten rat sarcoma viral oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MME membrane metallo-endopeptidase
NPTX2 neuronal pentraxin II
NPY1R neuropeptide Y receptor Y1
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM3 PDZ and LIM domain 3
PEX11A peroxisomal biogenesis factor 11 alpha
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHTF2 putative homeodomain transcription factor 2
PIP prolactin-induced protein
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PSCA prostate stem cell antigen
RTN1 reticulon 1
SCG2 secretogranin II
SHOX2 short stature homeobox 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
SV2C synaptic vesicle glycoprotein 2C
TAGLN transgelin
TBX2 T-box 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
VAV3 vav 3 guanine nucleotide exchange factor