BRD-K69932463_AZD-8055_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K69932463_AZD-8055_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPT1 angiopoietin 1
ANGPTL2 angiopoietin-like 2
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CCNG2 cyclin G2
CHMP4A charged multivesicular body protein 4A
COL6A3 collagen, type VI, alpha 3
CTSB cathepsin B
EGFR epidermal growth factor receptor
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA4 golgin A4
GPX3 glutathione peroxidase 3
HBP1 HMG-box transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLF6 Kruppel-like factor 6
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
MACF1 microtubule-actin crosslinking factor 1
MLPH melanophilin
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPIPB3 nuclear pore complex interacting protein family, member B3
PECR peroxisomal trans-2-enoyl-CoA reductase
PRUNE2 prune homolog 2 (Drosophila)
RGCC regulator of cell cycle
RNASET2 ribonuclease T2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TMEM135 transmembrane protein 135
TPP1 tripeptidyl peptidase I
TRIB1 tribbles pseudokinase 1
VAT1 vesicle amine transport 1
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
VWF von Willebrand factor
WDR45 WD repeat domain 45
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ATAD2 ATPase family, AAA domain containing 2
CBFB core-binding factor, beta subunit
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CENPU centromere protein U
CTPS1 CTP synthase 1
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FGFR3 fibroblast growth factor receptor 3
FKBP11 FK506 binding protein 11, 19 kDa
FKBP5 FK506 binding protein 5
GCH1 GTP cyclohydrolase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
HAT1 histone acetyltransferase 1
HSPA14 heat shock 70kDa protein 14
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KRT5 keratin 5, type II
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PDIA3 protein disulfide isomerase family A, member 3
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRAME preferentially expressed antigen in melanoma
PRKD3 protein kinase D3
PRPF4 pre-mRNA processing factor 4
PSPH phosphoserine phosphatase
RFC2 replication factor C (activator 1) 2, 40kDa
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
TMPO thymopoietin
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
USP1 ubiquitin specific peptidase 1
ZWINT ZW10 interacting kinetochore protein