BRD-K69932463_AZD-8055_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K69932463_AZD-8055_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
ANXA4 annexin A4
ATM ATM serine/threonine kinase
BHLHE41 basic helix-loop-helix family, member e41
CD9 CD9 molecule
COBL cordon-bleu WH2 repeat protein
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EAPP E2F-associated phosphoprotein
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
FMOD fibromodulin
FN1 fibronectin 1
HBP1 HMG-box transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDS iduronate 2-sulfatase
ITGAV integrin, alpha V
JAG1 jagged 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT8 keratin 8, type II
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
MACF1 microtubule-actin crosslinking factor 1
MAOB monoamine oxidase B
MGP matrix Gla protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPIPB3 nuclear pore complex interacting protein family, member B3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFC platelet derived growth factor C
PEG3 paternally expressed 3
PLAT plasminogen activator, tissue
PPAP2B phosphatidic acid phosphatase type 2B
PRKCQ protein kinase C, theta
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQSTM1 sequestosome 1
SRGN serglycin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TSPAN31 tetraspanin 31
WASF3 WAS protein family, member 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADM adrenomedullin
C20ORF24 chromosome 20 open reading frame 24
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CENPU centromere protein U
CFH complement factor H
DDIT4 DNA-damage-inducible transcript 4
EIF5A eukaryotic translation initiation factor 5A
G0S2 G0/G1 switch 2
GCH1 GTP cyclohydrolase 1
GSTA1 glutathione S-transferase alpha 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HP haptoglobin
IL13RA2 interleukin 13 receptor, alpha 2
IL1R2 interleukin 1 receptor, type II
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JMJD6 jumonji domain containing 6
KRT13 keratin 13, type I
MECOM MDS1 and EVI1 complex locus
NDC80 NDC80 kinetochore complex component
PCDH9 protocadherin 9
PRAME preferentially expressed antigen in melanoma
PRKCB protein kinase C, beta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS5 regulator of G-protein signaling 5
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
TCP1 t-complex 1
TSPAN13 tetraspanin 13
TUBG1 tubulin, gamma 1
TWIST1 twist family bHLH transcription factor 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VRK1 vaccinia related kinase 1