BRD-K69932463_AZD-8055_MCF7_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K69932463_AZD-8055_MCF7_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CA12 carbonic anhydrase XII
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CXCL9 chemokine (C-X-C motif) ligand 9
DICER1 dicer 1, ribonuclease type III
EPS8 epidermal growth factor receptor pathway substrate 8
FAM46A family with sequence similarity 46, member A
FGFR1 fibroblast growth factor receptor 1
FOXN3 forkhead box N3
GPX3 glutathione peroxidase 3
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
H3F3B H3 histone, family 3B (H3.3B)
HMOX1 heme oxygenase 1
IDO1 indoleamine 2,3-dioxygenase 1
IGF1R insulin-like growth factor 1 receptor
IGL immunoglobulin lambda locus
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LCK LCK proto-oncogene, Src family tyrosine kinase
LTB lymphotoxin beta (TNF superfamily, member 3)
MFAP2 microfibrillar-associated protein 2
MLPH melanophilin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLS3 plastin 3
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RBPMS RNA binding protein with multiple splicing
RNMT RNA (guanine-7-) methyltransferase
TBL1X transducin (beta)-like 1X-linked
TGFBI transforming growth factor, beta-induced, 68kDa
TRBC1 T cell receptor beta constant 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AK5 adenylate kinase 5
AMD1 adenosylmethionine decarboxylase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
CCNE2 cyclin E2
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COCH cochlin
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLX2 distal-less homeobox 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
E2F2 E2F transcription factor 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FSCN1 fascin actin-bundling protein 1
GAS2L1 growth arrest-specific 2 like 1
GATA2 GATA binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HMP19 HMP19 protein
JMJD6 jumonji domain containing 6
KLK6 kallikrein-related peptidase 6
KRT7 keratin 7, type II
MYLK myosin light chain kinase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPY neuropeptide Y
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRGN neurogranin (protein kinase C substrate, RC3)
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEA15 phosphoprotein enriched in astrocytes 15
PENK proenkephalin
PNMA2 paraneoplastic Ma antigen 2
PPIF peptidylprolyl isomerase F
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RCAN1 regulator of calcineurin 1
RGS4 regulator of G-protein signaling 4
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SFN stratifin
SNAP25 synaptosomal-associated protein, 25kDa
SNX11 sorting nexin 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
SYT1 synaptotagmin I
THBS1 thrombospondin 1
TPM4 tropomyosin 4
TSC22D2 TSC22 domain family, member 2
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WASF1 WAS protein family, member 1
ZEB2 zinc finger E-box binding homeobox 2