BRD-K69932463_AZD-8055_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

232 genes differentially expressed following the BRD-K69932463_AZD-8055_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AMOTL2 angiomotin like 2
ANGPTL2 angiopoietin-like 2
ANXA4 annexin A4
APOD apolipoprotein D
ARMCX2 armadillo repeat containing, X-linked 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BASP1 brain abundant, membrane attached signal protein 1
BCAS3 breast carcinoma amplified sequence 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CAPG capping protein (actin filament), gelsolin-like
CAPN1 calpain 1, (mu/I) large subunit
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CEP57 centrosomal protein 57kDa
CFB complement factor B
CIRBP cold inducible RNA binding protein
CP ceruloplasmin (ferroxidase)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DLG5 discs, large homolog 5 (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL2 dihydropyrimidinase-like 2
DUSP10 dual specificity phosphatase 10
EGFR epidermal growth factor receptor
ENO2 enolase 2 (gamma, neuronal)
F13A1 coagulation factor XIII, A1 polypeptide
FADS3 fatty acid desaturase 3
FAM127A family with sequence similarity 127, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FNBP1 formin binding protein 1
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GPX3 glutathione peroxidase 3
GSE1 Gse1 coiled-coil protein
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGA2 high mobility group AT-hook 2
HOXD1 homeobox D1
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP6 insulin-like growth factor binding protein 6
IRS1 insulin receptor substrate 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAV integrin, alpha V
ITGB4 integrin, beta 4
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JAG1 jagged 1
KDM5B lysine (K)-specific demethylase 5B
KDM5D lysine (K)-specific demethylase 5D
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
LXN latexin
MAP1B microtubule-associated protein 1B
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
NPC1 Niemann-Pick disease, type C1
NRIP1 nuclear receptor interacting protein 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
OSMR oncostatin M receptor
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPL periplakin
PTK2B protein tyrosine kinase 2 beta
PYCARD PYD and CARD domain containing
RBKS ribokinase
RELN reelin
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFXN3 sideroflexin 3
SLC16A6 solute carrier family 16, member 6
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STXBP1 syntaxin binding protein 1
SULF1 sulfatase 1
SYT17 synaptotagmin XVII
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TIMP2 TIMP metallopeptidase inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TRIM8 tripartite motif containing 8
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
YPEL5 yippee-like 5 (Drosophila)
ZC2HC1A zinc finger, C2HC-type containing 1A
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AURKA aurora kinase A
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
CACYBP calcyclin binding protein
CALR calreticulin
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHFR dihydrofolate reductase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FOXM1 forkhead box M1
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLIPR1 GLI pathogenesis-related 1
GTSE1 G-2 and S-phase expressed 1
H2AFZ H2A histone family, member Z
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIST1H4C histone cluster 1, H4c
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFI44 interferon-induced protein 44
IFRD2 interferon-related developmental regulator 2
IL1RN interleukin 1 receptor antagonist
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LRRC59 leucine rich repeat containing 59
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NLRP2 NLR family, pyrin domain containing 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFAS phosphoribosylformylglycinamidine synthase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
QDPR quinoid dihydropteridine reductase
RANBP1 RAN binding protein 1
RET ret proto-oncogene
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SDF2L1 stromal cell-derived factor 2-like 1
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC1A structural maintenance of chromosomes 1A
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORD sorbitol dehydrogenase
SRM spermidine synthase
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TMX1 thioredoxin-related transmembrane protein 1
TRIM14 tripartite motif containing 14
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein