BRD-K69932463_AZD-8055_LNCAP_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

273 genes differentially expressed following the BRD-K69932463_AZD-8055_LNCAP_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANKRD36B ankyrin repeat domain 36B
ASXL2 additional sex combs like transcriptional regulator 2
ATMIN ATM interactor
ATP9A ATPase, class II, type 9A
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPTF bromodomain PHD finger transcription factor
C6ORF62 chromosome 6 open reading frame 62
CAMLG calcium modulating ligand
CD24 CD24 molecule
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CST1 cystatin SN
DIAPH2 diaphanous-related formin 2
DUSP4 dual specificity phosphatase 4
ECHDC2 enoyl CoA hydratase domain containing 2
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
ELN elastin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETV1 ets variant 1
FNDC3B fibronectin type III domain containing 3B
FOXN3 forkhead box N3
FOXO3 forkhead box O3
FXR1 fragile X mental retardation, autosomal homolog 1
GATAD1 GATA zinc finger domain containing 1
GHR growth hormone receptor
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GSDMB gasdermin B
GSPT2 G1 to S phase transition 2
HBP1 HMG-box transcription factor 1
HEATR1 HEAT repeat containing 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HP haptoglobin
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KAT6B K(lysine) acetyltransferase 6B
KIZ kizuna centrosomal protein
LAMA3 laminin, alpha 3
LAMA5 laminin, alpha 5
LAMB2 laminin, beta 2 (laminin S)
LAMC2 laminin, gamma 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS8 lectin, galactoside-binding, soluble, 8
LIMS1 LIM and senescent cell antigen-like domains 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP1B microtubule-associated protein 1B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MARCKS myristoylated alanine-rich protein kinase C substrate
MED13 mediator complex subunit 13
MID1 midline 1
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MXI1 MAX interactor 1, dimerization protein
N4BP2L1 NEDD4 binding protein 2-like 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NPC1 Niemann-Pick disease, type C1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAWR PRKC, apoptosis, WT1, regulator
PCBP2 poly(rC) binding protein 2
PCM1 pericentriolar material 1
PDCD6 programmed cell death 6
PDGFC platelet derived growth factor C
PDLIM5 PDZ and LIM domain 5
PILRB paired immunoglobin-like type 2 receptor beta
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLXNA1 plexin A1
PPAP2A phosphatidic acid phosphatase type 2A
PPAP2B phosphatidic acid phosphatase type 2B
PTEN phosphatase and tensin homolog
PTN pleiotrophin
RAP1GAP RAP1 GTPase activating protein
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
RPL31 ribosomal protein L31
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SECISBP2L SECIS binding protein 2-like
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFRP4 secreted frizzled-related protein 4
SIDT2 SID1 transmembrane family, member 2
SMYD2 SET and MYND domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SPATA20 spermatogenesis associated 20
SPDEF SAM pointed domain containing ETS transcription factor
TARBP1 TAR (HIV-1) RNA binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TSC2 tuberous sclerosis 2
TTC3 tetratricopeptide repeat domain 3
TUG1 taurine up-regulated 1 (non-protein coding)
TXNIP thioredoxin interacting protein
URI1 URI1, prefoldin-like chaperone
USP34 ubiquitin specific peptidase 34
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WAC WW domain containing adaptor with coiled-coil
WDR45 WD repeat domain 45
YBX3 Y box binding protein 3
ZBTB20 zinc finger and BTB domain containing 20
ZCCHC6 zinc finger, CCHC domain containing 6
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AK2 adenylate kinase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
ATF3 activating transcription factor 3
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK2 cyclin-dependent kinase 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
COA3 cytochrome c oxidase assembly factor 3
CSTA cystatin A (stefin A)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO1 deiodinase, iodothyronine, type I
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP1 fatty acid binding protein 1, liver
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GATA3 GATA binding protein 3
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB7 homeobox B7
HOXC10 homeobox C10
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0101 KIAA0101
LMNB1 lamin B1
LMO4 LIM domain only 4
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARS methionyl-tRNA synthetase
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG2 non-SMC condensin II complex, subunit G2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRGN neurogranin (protein kinase C substrate, RC3)
ORC6 origin recognition complex, subunit 6
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRR15L proline rich 15-like
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RPL39L ribosomal protein L39-like
RRM2 ribonucleotide reductase M2
S100A14 S100 calcium binding protein A14
SDC1 syndecan 1
SDF2L1 stromal cell-derived factor 2-like 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMC1A structural maintenance of chromosomes 1A
SNAP25 synaptosomal-associated protein, 25kDa
SNX10 sorting nexin 10
SQLE squalene epoxidase
SRSF7 serine/arginine-rich splicing factor 7
STC2 stanniocalcin 2
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM177 transmembrane protein 177
TMEM194A transmembrane protein 194A
TMEM97 transmembrane protein 97
TRIB3 tribbles pseudokinase 3
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
VTCN1 V-set domain containing T cell activation inhibitor 1
ZWINT ZW10 interacting kinetochore protein