BRD-K69932463_AZD-8055_LNCAP_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

240 genes differentially expressed following the BRD-K69932463_AZD-8055_LNCAP_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTG2 actin, gamma 2, smooth muscle, enteric
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
AMACR alpha-methylacyl-CoA racemase
AREG amphiregulin
ARID5B AT rich interactive domain 5B (MRF1-like)
ATMIN ATM interactor
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BCAM basal cell adhesion molecule (Lutheran blood group)
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CLDN3 claudin 3
COL4A5 collagen, type IV, alpha 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
EDN1 endothelin 1
EGFR epidermal growth factor receptor
ESR1 estrogen receptor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FBXO21 F-box protein 21
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GJA1 gap junction protein, alpha 1, 43kDa
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GREB1 growth regulation by estrogen in breast cancer 1
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IDS iduronate 2-sulfatase
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KDM4B lysine (K)-specific demethylase 4B
LAMA3 laminin, alpha 3
LAMA5 laminin, alpha 5
LAPTM5 lysosomal protein transmembrane 5
LOC100272216 uncharacterized LOC100272216
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
MLPH melanophilin
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MOAP1 modulator of apoptosis 1
MZF1 myeloid zinc finger 1
N4BP2L2 NEDD4 binding protein 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUMA1 nuclear mitotic apparatus protein 1
OBSL1 obscurin-like 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDE4C phosphodiesterase 4C, cAMP-specific
PDZRN3 PDZ domain containing ring finger 3
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTN pleiotrophin
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPATA20 spermatogenesis associated 20
SPDEF SAM pointed domain containing ETS transcription factor
TBX3 T-box 3
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TRA2A transformer 2 alpha homolog (Drosophila)
TXNIP thioredoxin interacting protein
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF451 zinc finger protein 451
ZNF587 zinc finger protein 587
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ASCC3 activating signal cointegrator 1 complex subunit 3
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BHLHE40 basic helix-loop-helix family, member e40
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C10ORF10 chromosome 10 open reading frame 10
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNE2 cyclin E2
CCR2 chemokine (C-C motif) receptor 2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CLIC4 chloride intracellular channel 4
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DIO1 deiodinase, iodothyronine, type I
DNM1L dynamin 1-like
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO1 enolase 1, (alpha)
ERAP2 endoplasmic reticulum aminopeptidase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXM1 forkhead box M1
GARS glycyl-tRNA synthetase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GOT1 glutamic-oxaloacetic transaminase 1, soluble
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HSPA4L heat shock 70kDa protein 4-like
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LAP3 leucine aminopeptidase 3
LMO4 LIM domain only 4
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAMLD1 mastermind-like domain containing 1
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MICB MHC class I polypeptide-related sequence B
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PBX3 pre-B-cell leukemia homeobox 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PGD phosphogluconate dehydrogenase
PHGDH phosphoglycerate dehydrogenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP prolactin-induced protein
PLK4 polo-like kinase 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RPL39L ribosomal protein L39-like
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A9 S100 calcium binding protein A9
SDC2 syndecan 2
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
STMN1 stathmin 1
STMN2 stathmin 2
TACC3 transforming, acidic coiled-coil containing protein 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRBC1 T cell receptor beta constant 1
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
WARS tryptophanyl-tRNA synthetase
XPO7 exportin 7
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein