BRD-K69932463_AZD-8055_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K69932463_AZD-8055_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AIM2 absent in melanoma 2
ALAS2 5'-aminolevulinate synthase 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CDK19 cyclin-dependent kinase 19
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CTAG2 cancer/testis antigen 2
CTGF connective tissue growth factor
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DSP desmoplakin
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GNLY granulysin
HDAC6 histone deacetylase 6
HIST3H2A histone cluster 3, H2a
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP1 insulin-like growth factor binding protein 1
IRS1 insulin receptor substrate 1
KIZ kizuna centrosomal protein
KRT23 keratin 23, type I
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LEPR leptin receptor
LIMS1 LIM and senescent cell antigen-like domains 1
MT1X metallothionein 1X
MYO6 myosin VI
NKG7 natural killer cell granule protein 7
NMRK1 nicotinamide riboside kinase 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
OSBPL10 oxysterol binding protein-like 10
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAWR PRKC, apoptosis, WT1, regulator
PERP PERP, TP53 apoptosis effector
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTCH1 patched 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
S100A12 S100 calcium binding protein A12
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SF1 splicing factor 1
SF3A2 splicing factor 3a, subunit 2, 66kDa
SOX4 SRY (sex determining region Y)-box 4
STXBP2 syntaxin binding protein 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNS3 tensin 3
TPST2 tyrosylprotein sulfotransferase 2
TSPAN5 tetraspanin 5
TXNIP thioredoxin interacting protein
WDR13 WD repeat domain 13
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ACAT2 acetyl-CoA acetyltransferase 2
ACOT7 acyl-CoA thioesterase 7
AK4 adenylate kinase 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CBR3 carbonyl reductase 3
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CFH complement factor H
CSRP2 cysteine and glycine-rich protein 2
CTPS1 CTP synthase 1
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
ENO1 enolase 1, (alpha)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
GARS glycyl-tRNA synthetase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
IARS isoleucyl-tRNA synthetase
ICMT isoprenylcysteine carboxyl methyltransferase
IFI44L interferon-induced protein 44-like
LRP2 low density lipoprotein receptor-related protein 2
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYCBP MYC binding protein
NEFL neurofilament, light polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
PCNA proliferating cell nuclear antigen
PDGFRL platelet-derived growth factor receptor-like
PGAM1 phosphoglycerate mutase 1 (brain)
PGD phosphogluconate dehydrogenase
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITX1 paired-like homeodomain 1
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PSAT1 phosphoserine aminotransferase 1
QDPR quinoid dihydropteridine reductase
RANBP1 RAN binding protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SNAP25 synaptosomal-associated protein, 25kDa
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPP1 secreted phosphoprotein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TARS threonyl-tRNA synthetase
TFRC transferrin receptor
YARS tyrosyl-tRNA synthetase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta