BRD-K69932463_AZD-8055_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K69932463_AZD-8055_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AHNAK AHNAK nucleoprotein
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHIC2 cysteine-rich hydrophobic domain 2
CRYAB crystallin, alpha B
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HBP1 HMG-box transcription factor 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IGFBP6 insulin-like growth factor binding protein 6
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KRT17 keratin 17, type I
LGALS3 lectin, galactoside-binding, soluble, 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MCUR1 mitochondrial calcium uniporter regulator 1
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RALBP1 ralA binding protein 1
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TMEM135 transmembrane protein 135
TSC22D3 TSC22 domain family, member 3
USP6NL USP6 N-terminal like
WDR13 WD repeat domain 13

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANOS1 anosmin 1
AQP1 aquaporin 1 (Colton blood group)
CCNE2 cyclin E2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25A cell division cycle 25A
CHGB chromogranin B
COG7 component of oligomeric golgi complex 7
CXCL11 chemokine (C-X-C motif) ligand 11
CYTL1 cytokine-like 1
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DPH2 DPH2 homolog (S. cerevisiae)
DPT dermatopontin
FABP4 fatty acid binding protein 4, adipocyte
FASTKD5 FAST kinase domains 5
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GCH1 GTP cyclohydrolase 1
GNAS GNAS complex locus
GREM1 gremlin 1, DAN family BMP antagonist
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
MAP7 microtubule-associated protein 7
MAT2A methionine adenosyltransferase II, alpha
NR2F6 nuclear receptor subfamily 2, group F, member 6
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PIP prolactin-induced protein
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNAP25 synaptosomal-associated protein, 25kDa
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF512B zinc finger protein 512B