BRD-K69932463_AZD-8055_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

204 genes differentially expressed following the BRD-K69932463_AZD-8055_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADRB2 adrenoceptor beta 2, surface
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AMIGO2 adhesion molecule with Ig-like domain 2
ANO1 anoctamin 1, calcium activated chloride channel
ANXA4 annexin A4
AXL AXL receptor tyrosine kinase
BSG basigin (Ok blood group)
C6ORF48 chromosome 6 open reading frame 48
CCND1 cyclin D1
CD14 CD14 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFLAR CASP8 and FADD-like apoptosis regulator
COL18A1 collagen, type XVIII, alpha 1
COL4A5 collagen, type IV, alpha 5
COL8A2 collagen, type VIII, alpha 2
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP4 dual specificity phosphatase 4
ECHDC2 enoyl CoA hydratase domain containing 2
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EIF3F eukaryotic translation initiation factor 3, subunit F
EMP1 epithelial membrane protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN2 fibrillin 2
FGFR2 fibroblast growth factor receptor 2
FNBP1 formin binding protein 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GRN granulin
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HMGA2 high mobility group AT-hook 2
IDS iduronate 2-sulfatase
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS1 insulin receptor substrate 1
ISG15 ISG15 ubiquitin-like modifier
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LAMP2 lysosomal-associated membrane protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100505650 uncharacterized LOC100505650
MAN2B1 mannosidase, alpha, class 2B, member 1
METRN meteorin, glial cell differentiation regulator
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPIPB3 nuclear pore complex interacting protein family, member B3
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLA1A phospholipase A1 member A
PLEKHA5 pleckstrin homology domain containing, family A member 5
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RFTN1 raftlin, lipid raft linker 1
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RNMT RNA (guanine-7-) methyltransferase
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC16A6 solute carrier family 16, member 6
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SP100 SP100 nuclear antigen
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AGTR1 angiotensin II receptor, type 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CNN3 calponin 3, acidic
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EBP emopamil binding protein (sterol isomerase)
ENO1 enolase 1, (alpha)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
HIST1H4C histone cluster 1, H4c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA14 heat shock 70kDa protein 14
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD2 interferon-related developmental regulator 2
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT15 keratin 15, type I
LBR lamin B receptor
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
MKI67 marker of proliferation Ki-67
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NEBL nebulette
NEK2 NIMA-related kinase 2
NQO1 NAD(P)H dehydrogenase, quinone 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PIP prolactin-induced protein
PLK1 polo-like kinase 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RCAN1 regulator of calcineurin 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA3 replication protein A3, 14kDa
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCML1 sex comb on midleg-like 1 (Drosophila)
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPP1 secreted phosphoprotein 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACC3 transforming, acidic coiled-coil containing protein 3
TF transferrin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMPO thymopoietin
TNC tenascin C
TPX2 TPX2, microtubule-associated
TRIM2 tripartite motif containing 2
TRIM29 tripartite motif containing 29
TSPAN13 tetraspanin 13
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein