BRD-K69932463_AZD-8055_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K69932463_AZD-8055_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AREG amphiregulin
ATP9A ATPase, class II, type 9A
AXIN1 axin 1
BCL7A B-cell CLL/lymphoma 7A
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMLG calcium modulating ligand
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSK cathepsin K
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3H eukaryotic translation initiation factor 3, subunit H
ETHE1 ethylmalonic encephalopathy 1
F2R coagulation factor II (thrombin) receptor
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXN3 forkhead box N3
GATA3 GATA binding protein 3
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPNMB glycoprotein (transmembrane) nmb
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSN gelsolin
HAUS4 HAUS augmin-like complex, subunit 4
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IL2RG interleukin 2 receptor, gamma
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
INSM1 insulinoma-associated 1
IRS2 insulin receptor substrate 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP9 matrix metallopeptidase 9
NPDC1 neural proliferation, differentiation and control, 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OXA1L oxidase (cytochrome c) assembly 1-like
PDE4B phosphodiesterase 4B, cAMP-specific
PLCB4 phospholipase C, beta 4
POSTN periostin, osteoblast specific factor
PSIP1 PC4 and SFRS1 interacting protein 1
PTPRO protein tyrosine phosphatase, receptor type, O
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFTN1 raftlin, lipid raft linker 1
RGS5 regulator of G-protein signaling 5
RPL36 ribosomal protein L36
SATB1 SATB homeobox 1
SFRP4 secreted frizzled-related protein 4
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SPATA20 spermatogenesis associated 20
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SQSTM1 sequestosome 1
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TPP1 tripeptidyl peptidase I
TRH thyrotropin-releasing hormone
TSPAN4 tetraspanin 4
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALB albumin
ALDOC aldolase C, fructose-bisphosphate
APOA2 apolipoprotein A-II
ARF4 ADP-ribosylation factor 4
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C20ORF24 chromosome 20 open reading frame 24
CAV2 caveolin 2
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CDC20 cell division cycle 20
CETN2 centrin, EF-hand protein, 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CRELD2 cysteine-rich with EGF-like domains 2
CTSC cathepsin C
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EGF epidermal growth factor
EIF4E2 eukaryotic translation initiation factor 4E family member 2
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FKBP11 FK506 binding protein 11, 19 kDa
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
GPC3 glypican 3
GPX3 glutathione peroxidase 3
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
HYOU1 hypoxia up-regulated 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LDLR low density lipoprotein receptor
LRRC59 leucine rich repeat containing 59
MAL mal, T-cell differentiation protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MPZL1 myelin protein zero-like 1
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OAT ornithine aminotransferase
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDIA6 protein disulfide isomerase family A, member 6
PELO pelota homolog (Drosophila)
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RBP1 retinol binding protein 1, cellular
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERP1 stress-associated endoplasmic reticulum protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SQLE squalene epoxidase
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
STC1 stanniocalcin 1
TFG TRK-fused gene
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TMEM100 transmembrane protein 100
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TXNDC9 thioredoxin domain containing 9
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
VAMP8 vesicle-associated membrane protein 8