BRD-K69932463_AZD-8055_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K69932463_AZD-8055_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANXA1 annexin A1
AUH AU RNA binding protein/enoyl-CoA hydratase
BCAM basal cell adhesion molecule (Lutheran blood group)
BRD8 bromodomain containing 8
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFLAR CASP8 and FADD-like apoptosis regulator
CHL1 cell adhesion molecule L1-like
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CPD carboxypeptidase D
CYTH1 cytohesin 1
DST dystonin
ECHDC2 enoyl CoA hydratase domain containing 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAS Fas cell surface death receptor
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GADD45B growth arrest and DNA-damage-inducible, beta
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GRB7 growth factor receptor-bound protein 7
GRN granulin
HBP1 HMG-box transcription factor 1
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HTRA1 HtrA serine peptidase 1
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
KDM5A lysine (K)-specific demethylase 5A
KLHDC2 kelch domain containing 2
LAMP3 lysosomal-associated membrane protein 3
LBH limb bud and heart development
LGALS8 lectin, galactoside-binding, soluble, 8
LXN latexin
MAN2A1 mannosidase, alpha, class 2A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MVP major vault protein
N4BP2L1 NEDD4 binding protein 2-like 1
NAV2 neuron navigator 2
NBR1 neighbor of BRCA1 gene 1
NCOA2 nuclear receptor coactivator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NT5DC2 5'-nucleotidase domain containing 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PERP PERP, TP53 apoptosis effector
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLXNB2 plexin B2
PNRC1 proline-rich nuclear receptor coactivator 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKCD protein kinase C, delta
RB1CC1 RB1-inducible coiled-coil 1
RBM47 RNA binding motif protein 47
RGCC regulator of cell cycle
RNF44 ring finger protein 44
RPL31 ribosomal protein L31
RPS27L ribosomal protein S27-like
RSRP1 arginine/serine-rich protein 1
S100A14 S100 calcium binding protein A14
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOS2 son of sevenless homolog 2 (Drosophila)
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TFPI2 tissue factor pathway inhibitor 2
TGIF1 TGFB-induced factor homeobox 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC6A trafficking protein particle complex 6A
TRIM22 tripartite motif containing 22
VCAN versican
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AK2 adenylate kinase 2
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA10 annexin A10
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3ORF14 chromosome 3 open reading frame 14
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CTPS1 CTP synthase 1
CTSE cathepsin E
DES desmin
DHCR7 7-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FAM57A family with sequence similarity 57, member A
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GGCT gamma-glutamylcyclotransferase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HK2 hexokinase 2
HOMER1 homer scaffolding protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KRT17 keratin 17, type I
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAP1B microtubule-associated protein 1B
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MINA MYC induced nuclear antigen
MMP7 matrix metallopeptidase 7
MRPL12 mitochondrial ribosomal protein L12
MRPL42 mitochondrial ribosomal protein L42
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCH2 mitochondrial carrier 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH11 myosin, heavy chain 11, smooth muscle
NEB nebulin
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPTX2 neuronal pentraxin II
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFKP phosphofructokinase, platelet
PFN2 profilin 2
PGM1 phosphoglucomutase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLN phospholamban
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCB protein kinase C, beta
RAB29 RAB29, member RAS oncogene family
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RFC2 replication factor C (activator 1) 2, 40kDa
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SPINK1 serine peptidase inhibitor, Kazal type 1
SRM spermidine synthase
STRA13 stimulated by retinoic acid 13
SYNM synemin, intermediate filament protein
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
TPM1 tropomyosin 1 (alpha)
TRAPPC3 trafficking protein particle complex 3
TSPAN8 tetraspanin 8
TUBB6 tubulin, beta 6 class V