BRD-K69852452_7241-4207_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-K69852452_7241-4207_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKAP17A A kinase (PRKA) anchor protein 17A
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKRD10 ankyrin repeat domain 10
ANKRD12 ankyrin repeat domain 12
ANXA1 annexin A1
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
BIK BCL2-interacting killer (apoptosis-inducing)
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL15A1 collagen, type XV, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNM1L dynamin 1-like
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP1 dual specificity phosphatase 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FXYD3 FXYD domain containing ion transport regulator 3
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GLA galactosidase, alpha
GSR glutathione reductase
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDE insulin-degrading enzyme
IFRD1 interferon-related developmental regulator 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT5 keratin 5, type II
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LBH limb bud and heart development
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LIMS1 LIM and senescent cell antigen-like domains 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEB2 melanoma antigen family B2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MORC4 MORC family CW-type zinc finger 4
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NAMPT nicotinamide phosphoribosyltransferase
NAV3 neuron navigator 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NKX3-1 NK3 homeobox 1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
PIR pirin (iron-binding nuclear protein)
PLAUR plasminogen activator, urokinase receptor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
RSRP1 arginine/serine-rich protein 1
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SPP1 secreted phosphoprotein 1
SRGN serglycin
STOM stomatin
TBP TATA box binding protein
TBPL1 TBP-like 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM16 tripartite motif containing 16
TXNL1 thioredoxin-like 1
TXNRD1 thioredoxin reductase 1
UBE2A ubiquitin-conjugating enzyme E2A
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
B3GNT1
CES2 carboxylesterase 2
CHRDL1 chordin-like 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL3A1 collagen, type III, alpha 1
CTNND1 catenin (cadherin-associated protein), delta 1
CXADR coxsackie virus and adenovirus receptor
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DGKZ diacylglycerol kinase, zeta
DHCR24 24-dehydrocholesterol reductase
DMD dystrophin
EFNB3 ephrin-B3
ENO1 enolase 1, (alpha)
EPS8L2 EPS8-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP4 fatty acid binding protein 4, adipocyte
FABP7 fatty acid binding protein 7, brain
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FHL1 four and a half LIM domains 1
FXYD6 FXYD domain containing ion transport regulator 6
GPC4 glypican 4
GPM6A glycoprotein M6A
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLF hepatic leukemia factor
IL17RB interleukin 17 receptor B
ISOC1 isochorismatase domain containing 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LGALS4 lectin, galactoside-binding, soluble, 4
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100505650 uncharacterized LOC100505650
MAN1A1 mannosidase, alpha, class 1A, member 1
NEBL nebulette
NR2F6 nuclear receptor subfamily 2, group F, member 6
NTAN1 N-terminal asparagine amidase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCLO piccolo presynaptic cytomatrix protein
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG10 paternally expressed 10
PMM2 phosphomannomutase 2
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PXDN peroxidasin
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFTN1 raftlin, lipid raft linker 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SDC1 syndecan 1
SDC2 syndecan 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPI1 triosephosphate isomerase 1
TSPAN12 tetraspanin 12
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I