BRD-K69840642_HDAC6 inhibitor ISOX_RMGI_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_RMGI_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
AFF1 AF4/FMR2 family, member 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD1E CD1e molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHN2 chimerin 2
CHPT1 choline phosphotransferase 1
CR2 complement component (3d/Epstein Barr virus) receptor 2
CSRP1 cysteine and glycine-rich protein 1
CTSE cathepsin E
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK1 death-associated protein kinase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EIF5A eukaryotic translation initiation factor 5A
FAM98A family with sequence similarity 98, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FYB FYN binding protein
GCH1 GTP cyclohydrolase 1
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLGA7 golgin A7
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HN1 hematological and neurological expressed 1
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
ILK integrin-linked kinase
INHBA inhibin, beta A
ITM2C integral membrane protein 2C
JAM3 junctional adhesion molecule 3
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LPXN leupaxin
MAGEA3 melanoma antigen family A3
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
METTL7A methyltransferase like 7A
MGST3 microsomal glutathione S-transferase 3
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NEBL nebulette
NOSIP nitric oxide synthase interacting protein
OSBPL8 oxysterol binding protein-like 8
PALLD palladin, cytoskeletal associated protein
PLA2G15 phospholipase A2, group XV
POLB polymerase (DNA directed), beta
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PSAP prosaposin
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RGS2 regulator of G-protein signaling 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RTN3 reticulon 3
SFRP1 secreted frizzled-related protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STOM stomatin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAPPC4 trafficking protein particle complex 4
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADORA2B adenosine A2b receptor
AKR1C2 aldo-keto reductase family 1, member C2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1ORF106 chromosome 1 open reading frame 106
CADM1 cell adhesion molecule 1
CCND1 cyclin D1
CCNE2 cyclin E2
CD44 CD44 molecule (Indian blood group)
CD93 CD93 molecule
CRABP2 cellular retinoic acid binding protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR4 chemokine (C-X-C motif) receptor 4
DACH1 dachshund family transcription factor 1
DST dystonin
EFS embryonal Fyn-associated substrate
EREG epiregulin
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FOSL1 FOS-like antigen 1
GPX2 glutathione peroxidase 2
HMGA2 high mobility group AT-hook 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
KEAP1 kelch-like ECH-associated protein 1
KRT13 keratin 13, type I
KRT14 keratin 14, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LY6D lymphocyte antigen 6 complex, locus D
MAPK13 mitogen-activated protein kinase 13
MCM7 minichromosome maintenance complex component 7
MFAP5 microfibrillar associated protein 5
MSMB microseminoprotein, beta-
MTA1 metastasis associated 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP prolactin-induced protein
PLK1 polo-like kinase 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PUF60 poly-U binding splicing factor 60KDa
RAB38 RAB38, member RAS oncogene family
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
UBE2E3 ubiquitin-conjugating enzyme E2E 3
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91