BRD-K69840642_HDAC6 inhibitor ISOX_NCIH596_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_NCIH596_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ADAM10 ADAM metallopeptidase domain 10
ADCY9 adenylate cyclase 9
ALDOC aldolase C, fructose-bisphosphate
ASRGL1 asparaginase like 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHGB chromogranin B
CLIC4 chloride intracellular channel 4
CORO1A coronin, actin binding protein, 1A
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFNB2 ephrin-B2
EPAS1 endothelial PAS domain protein 1
EZR ezrin
FBP1 fructose-1,6-bisphosphatase 1
FGD6 FYVE, RhoGEF and PH domain containing 6
FOXO4 forkhead box O4
GRN granulin
GSN gelsolin
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IGFBP5 insulin-like growth factor binding protein 5
IQGAP1 IQ motif containing GTPase activating protein 1
ITM2C integral membrane protein 2C
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCTD12 potassium channel tetramerization domain containing 12
KCTD5 potassium channel tetramerization domain containing 5
KIAA0226L KIAA0226-like
KLHL24 kelch-like family member 24
L1CAM L1 cell adhesion molecule
LOC100505650 uncharacterized LOC100505650
MAGED2 melanoma antigen family D2
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
NAGK N-acetylglucosamine kinase
NEFL neurofilament, light polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NOSIP nitric oxide synthase interacting protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK5 proprotein convertase subtilisin/kexin type 5
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PLA2G15 phospholipase A2, group XV
PNMA2 paraneoplastic Ma antigen 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RBPMS RNA binding protein with multiple splicing
RHOB ras homolog family member B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOCS2 suppressor of cytokine signaling 2
SORT1 sortilin 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
STXBP1 syntaxin binding protein 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13
VAV3 vav 3 guanine nucleotide exchange factor
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BEX1 brain expressed, X-linked 1
C1R complement component 1, r subcomponent
C6ORF62 chromosome 6 open reading frame 62
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CD58 CD58 molecule
CELF2 CUGBP, Elav-like family member 2
CFH complement factor H
CTBP1 C-terminal binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCTD dCMP deaminase
DEK DEK proto-oncogene
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP22 dual specificity phosphatase 22
DUSP4 dual specificity phosphatase 4
DUT deoxyuridine triphosphatase
EIF5A eukaryotic translation initiation factor 5A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP3 epithelial membrane protein 3
F12 coagulation factor XII (Hageman factor)
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GATAD1 GATA zinc finger domain containing 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GPM6B glycoprotein M6B
GSAP gamma-secretase activating protein
GULP1 GULP, engulfment adaptor PTB domain containing 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HOXA10 homeobox A10
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISG20 interferon stimulated exonuclease gene 20kDa
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LIMCH1 LIM and calponin homology domains 1
LIPT1 lipoyltransferase 1
LTF lactotransferrin
MAPK6 mitogen-activated protein kinase 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSL1 male-specific lethal 1 homolog (Drosophila)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
PGC progastricsin (pepsinogen C)
PIR pirin (iron-binding nuclear protein)
PRR7 proline rich 7 (synaptic)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB13 RAB13, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
S100A7 S100 calcium binding protein A7
SFN stratifin
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNRPE small nuclear ribonucleoprotein polypeptide E
SORD sorbitol dehydrogenase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
TUBB6 tubulin, beta 6 class V
TXNDC9 thioredoxin domain containing 9
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WBP5 WW domain binding protein 5
ZFP36L2 ZFP36 ring finger protein-like 2
ZIC1 Zic family member 1