BRD-K69840642_HDAC6 inhibitor ISOX_NCIH1694_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_NCIH1694_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ALDOC aldolase C, fructose-bisphosphate
ANGPT1 angiopoietin 1
APLP2 amyloid beta (A4) precursor-like protein 2
ATM ATM serine/threonine kinase
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD9 CD9 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLC Charcot-Leyden crystal galectin
CLGN calmegin
CLU clusterin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSTB cystatin B (stefin B)
CTSA cathepsin A
CTSZ cathepsin Z
CXCL2 chemokine (C-X-C motif) ligand 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DEFA4 defensin, alpha 4, corticostatin
DHRS2 dehydrogenase/reductase (SDR family) member 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESYT1 extended synaptotagmin-like protein 1
FAM117A family with sequence similarity 117, member A
FAM65B family with sequence similarity 65, member B
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GUSBP3 glucuronidase, beta pseudogene 3
HSPA1A heat shock 70kDa protein 1A
IFI30 interferon, gamma-inducible protein 30
KCTD12 potassium channel tetramerization domain containing 12
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF2 Kruppel-like factor 2
KRT17 keratin 17, type I
LCN2 lipocalin 2
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MYO10 myosin X
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
OAT ornithine aminotransferase
OSBPL8 oxysterol binding protein-like 8
PDGFC platelet derived growth factor C
PLA2G15 phospholipase A2, group XV
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCI protein kinase C, iota
PRSS21 protease, serine, 21 (testisin)
RAD9A RAD9 homolog A (S. pombe)
RBP4 retinol binding protein 4, plasma
RGS10 regulator of G-protein signaling 10
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRBP1 ribosome binding protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SSR1 signal sequence receptor, alpha
SST somatostatin
TDO2 tryptophan 2,3-dioxygenase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TPST2 tyrosylprotein sulfotransferase 2
TWSG1 twisted gastrulation BMP signaling modulator 1
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBED2 zinc finger, BED-type containing 2
ZMAT3 zinc finger, matrin-type 3
ZNF217 zinc finger protein 217
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
ANK2 ankyrin 2, neuronal
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AQP3 aquaporin 3 (Gill blood group)
ASCL1 achaete-scute family bHLH transcription factor 1
ASPN asporin
C10ORF10 chromosome 10 open reading frame 10
CCNE2 cyclin E2
CD320 CD320 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CELF2 CUGBP, Elav-like family member 2
CHRDL1 chordin-like 1
COG2 component of oligomeric golgi complex 2
COL21A1 collagen, type XXI, alpha 1
CYC1 cytochrome c-1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DERA deoxyribose-phosphate aldolase (putative)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXOSC8 exosome component 8
FABP7 fatty acid binding protein 7, brain
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FOXJ3 forkhead box J3
FRZB frizzled-related protein
FXYD6 FXYD domain containing ion transport regulator 6
GRB7 growth factor receptor-bound protein 7
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HILPDA hypoxia inducible lipid droplet-associated
HOXA5 homeobox A5
HOXB7 homeobox B7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP4 insulin-like growth factor binding protein 4
LMO3 LIM domain only 3 (rhombotin-like 2)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MRPL15 mitochondrial ribosomal protein L15
MRPL46 mitochondrial ribosomal protein L46
MRPS18B mitochondrial ribosomal protein S18B
MSMB microseminoprotein, beta-
MTERF3 mitochondrial transcription termination factor 3
NDRG2 NDRG family member 2
NID1 nidogen 1
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP85 nucleoporin 85kDa
OBSL1 obscurin-like 1
OLFM1 olfactomedin 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PGAP3 post-GPI attachment to proteins 3
PLK1 polo-like kinase 1
PLN phospholamban
PON2 paraoxonase 2
PPOX protoporphyrinogen oxidase
PRDX2 peroxiredoxin 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PUF60 poly-U binding splicing factor 60KDa
PWP1 PWP1 homolog (S. cerevisiae)
RBP1 retinol binding protein 1, cellular
RFC2 replication factor C (activator 1) 2, 40kDa
RGS5 regulator of G-protein signaling 5
RNH1 ribonuclease/angiogenin inhibitor 1
RPIA ribose 5-phosphate isomerase A
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCAND1 SCAN domain containing 1
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC43A3 solute carrier family 43, member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SPARCL1 SPARC-like 1 (hevin)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SRI sorcin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF12 transcription factor 12
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM9SF3 transmembrane 9 superfamily member 3
TMEM176B transmembrane protein 176B
TMPO thymopoietin
TMSB15B thymosin beta 15B
TRIM9 tripartite motif containing 9
UQCRB ubiquinol-cytochrome c reductase binding protein
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZEB1 zinc finger E-box binding homeobox 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1