BRD-K69840642_HDAC6 inhibitor ISOX_LOVO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

229 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_LOVO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ACAA1 acetyl-CoA acyltransferase 1
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
AMDHD2 amidohydrolase domain containing 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ASMTL acetylserotonin O-methyltransferase-like
ATG2A autophagy related 2A
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAD BCL2-associated agonist of cell death
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CCNG2 cyclin G2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CNN3 calponin 3, acidic
CORO1A coronin, actin binding protein, 1A
CYB5R1 cytochrome b5 reductase 1
CYLD cylindromatosis (turban tumor syndrome)
DUSP10 dual specificity phosphatase 10
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FBXL12 F-box and leucine-rich repeat protein 12
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA7 golgin A7
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
GUK1 guanylate kinase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA2 heat shock 70kDa protein 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
ITM2C integral membrane protein 2C
LEFTY1 left-right determination factor 1
LPIN1 lipin 1
LPXN leupaxin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MAST3 microtubule associated serine/threonine kinase 3
MCOLN1 mucolipin 1
METRN meteorin, glial cell differentiation regulator
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MGST3 microsomal glutathione S-transferase 3
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NME7 NME/NM23 family member 7
NOSIP nitric oxide synthase interacting protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PEG10 paternally expressed 10
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLD3 phospholipase D family, member 3
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCD protein kinase C, delta
PSENEN presenilin enhancer gamma secretase subunit
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RAP2A RAP2A, member of RAS oncogene family
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SARAF store-operated calcium entry-associated regulatory factor
SC5D sterol-C5-desaturase
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC46A3 solute carrier family 46, member 3
SNX11 sorting nexin 11
SRPX sushi-repeat containing protein, X-linked
SST somatostatin
STX7 syntaxin 7
TBPL1 TBP-like 1
TKTL1 transketolase-like 1
TMEM41B transmembrane protein 41B
TOB1 transducer of ERBB2, 1
TRAK2 trafficking protein, kinesin binding 2
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADIRF adipogenesis regulatory factor
AGTR1 angiotensin II receptor, type 1
AKAP8 A kinase (PRKA) anchor protein 8
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA2 annexin A2
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
BMP4 bone morphogenetic protein 4
BTN3A2 butyrophilin, subfamily 3, member A2
C3 complement component 3
CADPS2 Ca++-dependent secretion activator 2
CAST calpastatin
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CST7 cystatin F (leukocystatin)
CTPS1 CTP synthase 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DKK1 dickkopf WNT signaling pathway inhibitor 1
ERBB2 erb-b2 receptor tyrosine kinase 2
EREG epiregulin
ESR1 estrogen receptor 1
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HMGB2 high mobility group box 2
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KAZN kazrin, periplakin interacting protein
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KIAA0368 KIAA0368
KIF5B kinesin family member 5B
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LTF lactotransferrin
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MICALL1 MICAL-like 1
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUP62 nucleoporin 62kDa
PDGFA platelet-derived growth factor alpha polypeptide
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PSCA prostate stem cell antigen
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAD23B RAD23 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SLAMF7 SLAM family member 7
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYT1 synaptotagmin I
TF transferrin
TIMP1 TIMP metallopeptidase inhibitor 1
TLK1 tousled-like kinase 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIM29 tripartite motif containing 29
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
ZBTB38 zinc finger and BTB domain containing 38