BRD-K69840642_HDAC6 inhibitor ISOX_JHUEM2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_JHUEM2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACOT7 acyl-CoA thioesterase 7
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ARPP21 cAMP-regulated phosphoprotein, 21kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLVRB biliverdin reductase B
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHMP2B charged multivesicular body protein 2B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CORO1A coronin, actin binding protein, 1A
CPA3 carboxypeptidase A3 (mast cell)
CREG1 cellular repressor of E1A-stimulated genes 1
CSRP1 cysteine and glycine-rich protein 1
CST6 cystatin E/M
DUSP10 dual specificity phosphatase 10
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
ITM2A integral membrane protein 2A
KRT7 keratin 7, type II
LIMA1 LIM domain and actin binding 1
LIPA lipase A, lysosomal acid, cholesterol esterase
METRN meteorin, glial cell differentiation regulator
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NLRP2 NLR family, pyrin domain containing 2
PAWR PRKC, apoptosis, WT1, regulator
PLA2G15 phospholipase A2, group XV
PLS1 plastin 1
PRKCZ protein kinase C, zeta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOB ras homolog family member B
RNF167 ring finger protein 167
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STOM stomatin
STX1A syntaxin 1A (brain)
SYNE1 spectrin repeat containing, nuclear envelope 1
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM41B transmembrane protein 41B
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
VAMP8 vesicle-associated membrane protein 8
XCL1 chemokine (C motif) ligand 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACAA2 acetyl-CoA acyltransferase 2
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP9 aquaporin 9
ATF5 activating transcription factor 5
BHLHE41 basic helix-loop-helix family, member e41
BID BH3 interacting domain death agonist
CBFB core-binding factor, beta subunit
CCNG1 cyclin G1
CIRBP cold inducible RNA binding protein
COL9A3 collagen, type IX, alpha 3
CXCL14 chemokine (C-X-C motif) ligand 14
FASN fatty acid synthase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAA glucosidase, alpha; acid
GAS2 growth arrest-specific 2
GNAS GNAS complex locus
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
ITGB5 integrin, beta 5
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
LEPR leptin receptor
LIMS1 LIM and senescent cell antigen-like domains 1
LOX lysyl oxidase
MARCKSL1 MARCKS-like 1
MECOM MDS1 and EVI1 complex locus
MICALL1 MICAL-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MX2 MX dynamin-like GTPase 2
MZT2A mitotic spindle organizing protein 2A
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLIN1 perilipin 1
PLK1 polo-like kinase 1
PSPH phosphoserine phosphatase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REPIN1 replication initiator 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS27L ribosomal protein S27-like
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD1 SMAD family member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNAI2 snail family zinc finger 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
THAP11 THAP domain containing 11
THBS1 thrombospondin 1
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TM4SF1 transmembrane 4 L six family member 1
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
TP53 tumor protein p53
TSKU tsukushi, small leucine rich proteoglycan
TXNDC9 thioredoxin domain containing 9
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBQLN2 ubiquilin 2
USP22 ubiquitin specific peptidase 22
ZMYND11 zinc finger, MYND-type containing 11