BRD-K69840642_HDAC6 inhibitor ISOX_A673_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_A673_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CAPG capping protein (actin filament), gelsolin-like
CCL20 chemokine (C-C motif) ligand 20
CCND3 cyclin D3
CD47 CD47 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COG5 component of oligomeric golgi complex 5
CPM carboxypeptidase M
CST6 cystatin E/M
CTSK cathepsin K
CTSW cathepsin W
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP10 dual specificity phosphatase 10
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL5 ELOVL fatty acid elongase 5
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IQCK IQ motif containing K
IQGAP1 IQ motif containing GTPase activating protein 1
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
KRT19 keratin 19, type I
LCN2 lipocalin 2
LIPA lipase A, lysosomal acid, cholesterol esterase
LITAF lipopolysaccharide-induced TNF factor
LUC7L3 LUC7-like 3 (S. cerevisiae)
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFSD10 major facilitator superfamily domain containing 10
MLF1 myeloid leukemia factor 1
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRO protein tyrosine phosphatase, receptor type, O
PYCARD PYD and CARD domain containing
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SMYD3 SET and MYND domain containing 3
SON SON DNA binding protein
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
STXBP1 syntaxin binding protein 1
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TTC3 tetratricopeptide repeat domain 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ARID1A AT rich interactive domain 1A (SWI-like)
AUTS2 autism susceptibility candidate 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX1 brain expressed, X-linked 1
CANT1 calcium activated nucleotidase 1
CCND2 cyclin D2
CD200 CD200 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
DACH1 dachshund family transcription factor 1
DCTD dCMP deaminase
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FAM60A family with sequence similarity 60, member A
FSCN1 fascin actin-bundling protein 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GNPDA1 glucosamine-6-phosphate deaminase 1
GREM1 gremlin 1, DAN family BMP antagonist
GSTO1 glutathione S-transferase omega 1
HMGN3 high mobility group nucleosomal binding domain 3
IFI16 interferon, gamma-inducible protein 16
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT6B keratin 6B, type II
LRRC41 leucine rich repeat containing 41
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MDK midkine (neurite growth-promoting factor 2)
MYH11 myosin, heavy chain 11, smooth muscle
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NID1 nidogen 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F6 nuclear receptor subfamily 2, group F, member 6
PARP2 poly (ADP-ribose) polymerase 2
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
QKI QKI, KH domain containing, RNA binding
SCAND1 SCAN domain containing 1
SFRP1 secreted frizzled-related protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX11 SRY (sex determining region Y)-box 11
SOX2 SRY (sex determining region Y)-box 2
SPAG7 sperm associated antigen 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPEN spen family transcriptional repressor
SPRY2 sprouty homolog 2 (Drosophila)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TLK2 tousled-like kinase 2
TMPO thymopoietin
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VCAN versican