BRD-K69840642_HDAC6 inhibitor ISOX_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

428 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACKR3 atypical chemokine receptor 3
ACLY ATP citrate lyase
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHCYL1 adenosylhomocysteinase-like 1
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARID5B AT rich interactive domain 5B (MRF1-like)
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BCL6 B-cell CLL/lymphoma 6
BLVRB biliverdin reductase B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
C5AR1 complement component 5a receptor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCDC69 coiled-coil domain containing 69
CCDC85B coiled-coil domain containing 85B
CCL4 chemokine (C-C motif) ligand 4
CCNA1 cyclin A1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
CLPTM1 cleft lip and palate associated transmembrane protein 1
COL1A1 collagen, type I, alpha 1
CORO1A coronin, actin binding protein, 1A
CPA3 carboxypeptidase A3 (mast cell)
CRABP2 cellular retinoic acid binding protein 2
CREG1 cellular repressor of E1A-stimulated genes 1
CTGF connective tissue growth factor
CTSA cathepsin A
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPP4 dipeptidyl-peptidase 4
DPT dermatopontin
DSTN destrin (actin depolymerizing factor)
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB2 ephrin-B2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
F11R F11 receptor
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
G0S2 G0/G1 switch 2
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNS glucosamine (N-acetyl)-6-sulfatase
GPX3 glutathione peroxidase 3
GRN granulin
GSTA4 glutathione S-transferase alpha 4
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT27 intraflagellar transport 27
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
INSIG1 insulin induced gene 1
IPO13 importin 13
IRS1 insulin receptor substrate 1
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
JUNB jun B proto-oncogene
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
LAMP2 lysosomal-associated membrane protein 2
LBH limb bud and heart development
LGALS3 lectin, galactoside-binding, soluble, 3
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LTBP1 latent transforming growth factor beta binding protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MAST3 microtubule associated serine/threonine kinase 3
MCOLN1 mucolipin 1
MGST3 microsomal glutathione S-transferase 3
MIR22HG MIR22 host gene
MMD monocyte to macrophage differentiation-associated
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELFE negative elongation factor complex member E
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NIT1 nitrilase 1
NME7 NME/NM23 family member 7
NPC1 Niemann-Pick disease, type C1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POR P450 (cytochrome) oxidoreductase
PSAP prosaposin
PTN pleiotrophin
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBKS ribokinase
RGS2 regulator of G-protein signaling 2
RRAD Ras-related associated with diabetes
RRAGD Ras-related GTP binding D
RTN2 reticulon 2
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFTPC surfactant protein C
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SKAP2 src kinase associated phosphoprotein 2
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SND1 staphylococcal nuclease and tudor domain containing 1
SOD2 superoxide dismutase 2, mitochondrial
SPTSSA serine palmitoyltransferase, small subunit A
SQSTM1 sequestosome 1
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STAR steroidogenic acute regulatory protein
SUSD4 sushi domain containing 4
THBD thrombomodulin
THEMIS2 thymocyte selection associated family member 2
TM7SF2 transmembrane 7 superfamily member 2
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TSPAN5 tetraspanin 5
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WISP2 WNT1 inducible signaling pathway protein 2
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADAM12 ADAM metallopeptidase domain 12
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOL1 apolipoprotein L, 1
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AURKA aurora kinase A
AURKB aurora kinase B
BACE2 beta-site APP-cleaving enzyme 2
BCLAF1 BCL2-associated transcription factor 1
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CASD1 CAS1 domain containing 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBFB core-binding factor, beta subunit
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNG1 cyclin G1
CD302 CD302 molecule
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CELF2 CUGBP, Elav-like family member 2
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP170 centrosomal protein 170kDa
CHEK1 checkpoint kinase 1
CKAP2 cytoskeleton associated protein 2
CLIC2 chloride intracellular channel 2
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COCH cochlin
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL9A3 collagen, type IX, alpha 3
CST3 cystatin C
DCK deoxycytidine kinase
DCTD dCMP deaminase
DEK DEK proto-oncogene
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ECT2 epithelial cell transforming 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM57A family with sequence similarity 57, member A
FBN1 fibrillin 1
FERMT1 fermitin family member 1
FLT3 fms-related tyrosine kinase 3
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
FXN frataxin
FXYD3 FXYD domain containing ion transport regulator 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSAP gamma-secretase activating protein
GTSE1 G-2 and S-phase expressed 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNMT histamine N-methyltransferase
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HOXA10 homeobox A10
HOXB2 homeobox B2
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL27RA interleukin 27 receptor, alpha
IRAK1 interleukin-1 receptor-associated kinase 1
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT5 keratin 5, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMNB1 lamin B1
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRRC41 leucine rich repeat containing 41
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANSC1 MANSC domain containing 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MECOM MDS1 and EVI1 complex locus
MGST2 microsomal glutathione S-transferase 2
MIA melanoma inhibitory activity
MICALL1 MICAL-like 1
MOK MOK protein kinase
MSRA methionine sulfoxide reductase A
MUC5B mucin 5B, oligomeric mucus/gel-forming
NBN nibrin
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NNT nicotinamide nucleotide transhydrogenase
NPDC1 neural proliferation, differentiation and control, 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSL1 obscurin-like 1
PBK PDZ binding kinase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDIA3 protein disulfide isomerase family A, member 3
PHACTR2 phosphatase and actin regulator 2
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PMF1 polyamine-modulated factor 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PRC1 protein regulator of cytokinesis 1
PRNP prion protein
PROM1 prominin 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PXDN peroxidasin
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
RPS27L ribosomal protein S27-like
RRM2 ribonucleotide reductase M2
SCRN1 secernin 1
SEPHS1 selenophosphate synthetase 1
SEPT11 septin 11
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC2 structural maintenance of chromosomes 2
SNX10 sorting nexin 10
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SPAG7 sperm associated antigen 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STAG2 stromal antigen 2
STMN1 stathmin 1
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF4 transcription factor 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFDP1 transcription factor Dp-1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMELESS timeless circadian clock
TLR4 toll-like receptor 4
TMF1 TATA element modulatory factor 1
TNPO1 transportin 1
TOR1A torsin family 1, member A (torsin A)
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TRIM22 tripartite motif containing 22
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UGDH UDP-glucose 6-dehydrogenase
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VBP1 von Hippel-Lindau binding protein 1
ZEB1 zinc finger E-box binding homeobox 1
ZMYND11 zinc finger, MYND-type containing 11
ZNF512B zinc finger protein 512B
ZWINT ZW10 interacting kinetochore protein