BRD-K69159985_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K69159985_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACAT1 acetyl-CoA acetyltransferase 1
ANKRD10 ankyrin repeat domain 10
ARHGAP29 Rho GTPase activating protein 29
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASS1 argininosuccinate synthase 1
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
CA2 carbonic anhydrase II
CARD10 caspase recruitment domain family, member 10
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL6A2 collagen, type VI, alpha 2
CXCL12 chemokine (C-X-C motif) ligand 12
DFNA5 deafness, autosomal dominant 5
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGFR epidermal growth factor receptor
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
GAL galanin/GMAP prepropeptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
IFNGR1 interferon gamma receptor 1
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KRT8 keratin 8, type II
LPAR1 lysophosphatidic acid receptor 1
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MT1HL1 metallothionein 1H-like 1
NLRP2 NLR family, pyrin domain containing 2
NNMT nicotinamide N-methyltransferase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PRUNE2 prune homolog 2 (Drosophila)
PSD3 pleckstrin and Sec7 domain containing 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGS2 regulator of G-protein signaling 2
RRAD Ras-related associated with diabetes
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100P S100 calcium binding protein P
SDC4 syndecan 4
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SIK1 salt-inducible kinase 1
SIRPA signal-regulatory protein alpha
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TCF4 transcription factor 4
TFRC transferrin receptor
TLE4 transducin-like enhancer of split 4
TMEM47 transmembrane protein 47
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
TUBB2A tubulin, beta 2A class IIa
VCAN versican

decreased expression

Symbol Name
ANGPT1 angiopoietin 1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
CHRDL1 chordin-like 1
CNPY3 canopy FGF signaling regulator 3
F13A1 coagulation factor XIII, A1 polypeptide
GPC3 glypican 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGA6 integrin, alpha 6
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
PERP PERP, TP53 apoptosis effector
PTCH1 patched 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS4Y1 ribosomal protein S4, Y-linked 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SHROOM2 shroom family member 2
SLIT2 slit homolog 2 (Drosophila)
SYT1 synaptotagmin I
TCTA T-cell leukemia translocation altered