BRD-K68548958_-666_SW620_6.0_h_20.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

247 genes differentially expressed following the BRD-K68548958_-666_SW620_6.0_h_20.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
ADM adrenomedullin
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AVPI1 arginine vasopressin-induced 1
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
CACYBP calcyclin binding protein
CAPN2 calpain 2, (m/II) large subunit
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH19 cadherin 19, type 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COMP cartilage oligomeric matrix protein
CTH cystathionine gamma-lyase
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FADS3 fatty acid desaturase 3
FHL2 four and a half LIM domains 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GCLM glutamate-cysteine ligase, modifier subunit
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPC1 glypican 1
GPR137B G protein-coupled receptor 137B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HOXB6 homeobox B6
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL18 interleukin 18
IRS1 insulin receptor substrate 1
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
JUP junction plakoglobin
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MORC4 MORC family CW-type zinc finger 4
MRPL18 mitochondrial ribosomal protein L18
MTUS1 microtubule associated tumor suppressor 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NLRP2 NLR family, pyrin domain containing 2
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PRNP prion protein
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTER phosphotriesterase related
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAD23B RAD23 homolog B (S. cerevisiae)
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAI2 snail family zinc finger 2
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STIP1 stress-induced phosphoprotein 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TBX2 T-box 2
TMEM2 transmembrane protein 2
TMSB15A thymosin beta 15a
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPBG trophoblast glycoprotein
TPD52 tumor protein D52
TPD52L2 tumor protein D52-like 2
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UBE2B ubiquitin-conjugating enzyme E2B
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1
ZBTB10 zinc finger and BTB domain containing 10
ZBTB38 zinc finger and BTB domain containing 38
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AKAP8 A kinase (PRKA) anchor protein 8
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASCL1 achaete-scute family bHLH transcription factor 1
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKB aurora kinase B
B3GNT1
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CPA3 carboxypeptidase A3 (mast cell)
CST3 cystatin C
CXADR coxsackie virus and adenovirus receptor
DFNA5 deafness, autosomal dominant 5
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPM6A glycoprotein M6A
GPX1 glutathione peroxidase 1
GRWD1 glutamate-rich WD repeat containing 1
GTF3A general transcription factor IIIA
GTSE1 G-2 and S-phase expressed 1
HCP5 HLA complex P5 (non-protein coding)
HIST1H4C histone cluster 1, H4c
ITM2A integral membrane protein 2A
KANK1 KN motif and ankyrin repeat domains 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
LAMP5 lysosomal-associated membrane protein family, member 5
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
METTL7A methyltransferase like 7A
MRPL34 mitochondrial ribosomal protein L34
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NREP neuronal regeneration related protein
NUDCD3 NudC domain containing 3
PDGFA platelet-derived growth factor alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PGLS 6-phosphogluconolactonase
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RPIA ribose 5-phosphate isomerase A
S100A8 S100 calcium binding protein A8
SCAND1 SCAN domain containing 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
TRIM14 tripartite motif containing 14
VIM vimentin
VSNL1 visinin-like 1
WFS1 Wolfram syndrome 1 (wolframin)