BRD-K68548958_-666_MCF7_6.0_h_20.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K68548958_-666_MCF7_6.0_h_20.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CAPN2 calpain 2, (m/II) large subunit
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL1A1 collagen, type I, alpha 1
CTSL cathepsin L
CTSZ cathepsin Z
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGL2 fibrinogen-like 2
FTH1 ferritin, heavy polypeptide 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
KRT6A keratin 6A, type II
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MUC4 mucin 4, cell surface associated
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PERP PERP, TP53 apoptosis effector
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLK2 polo-like kinase 2
PSAP prosaposin
RGCC regulator of cell cycle
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SYNGR3 synaptogyrin 3
TGFBI transforming growth factor, beta-induced, 68kDa
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
C3 complement component 3
CCNF cyclin F
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
EDNRA endothelin receptor type A
EXOSC4 exosome component 4
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ITM2A integral membrane protein 2A
KRT19 keratin 19, type I
KRT7 keratin 7, type II
MREG melanoregulin
NCALD neurocalcin delta
NFIB nuclear factor I/B
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PEX11A peroxisomal biogenesis factor 11 alpha
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCD protein kinase C, delta
RFTN1 raftlin, lipid raft linker 1
RPS11 ribosomal protein S11
SRSF6 serine/arginine-rich splicing factor 6
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFRC transferrin receptor
UBE2G2 ubiquitin-conjugating enzyme E2G 2