BRD-K68548958_-666_HA1E_6.0_h_20.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K68548958_-666_HA1E_6.0_h_20.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD14 CD14 molecule
CD53 CD53 molecule
CD93 CD93 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CECR1 cat eye syndrome chromosome region, candidate 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
CNN3 calponin 3, acidic
COL15A1 collagen, type XV, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGL2 fibrinogen-like 2
FKBP4 FK506 binding protein 4, 59kDa
GAL galanin/GMAP prepropeptide
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IL32 interleukin 32
INHBA inhibin, beta A
INHBB inhibin, beta B
IVNS1ABP influenza virus NS1A binding protein
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KIAA0226L KIAA0226-like
KLK5 kallikrein-related peptidase 5
KRT23 keratin 23, type I
LAPTM5 lysosomal protein transmembrane 5
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MCL1 myeloid cell leukemia 1
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MUC16 mucin 16, cell surface associated
MYO1B myosin IB
NCF2 neutrophil cytosolic factor 2
NEFL neurofilament, light polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PDZD2 PDZ domain containing 2
PELI1 pellino E3 ubiquitin protein ligase 1
PLBD1 phospholipase B domain containing 1
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIRPA signal-regulatory protein alpha
SNAI2 snail family zinc finger 2
SNX10 sorting nexin 10
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC1 stanniocalcin 1
STIP1 stress-induced phosphoprotein 1
THBD thrombomodulin
TPD52 tumor protein D52
TREM2 triggering receptor expressed on myeloid cells 2
TYROBP TYRO protein tyrosine kinase binding protein
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACSF2 acyl-CoA synthetase family member 2
ADD3 adducin 3 (gamma)
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BIN1 bridging integrator 1
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHMP6 charged multivesicular body protein 6
CIRBP cold inducible RNA binding protein
CRIP1 cysteine-rich protein 1 (intestinal)
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYSL2 dihydropyrimidinase-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM117A family with sequence similarity 117, member A
FBLN1 fibulin 1
FLNB filamin B, beta
FZD7 frizzled class receptor 7
GMDS GDP-mannose 4,6-dehydratase
HOXA5 homeobox A5
KDM5D lysine (K)-specific demethylase 5D
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTBP1 latent transforming growth factor beta binding protein 1
MAGED1 melanoma antigen family D1
MIR22HG MIR22 host gene
MSRB2 methionine sulfoxide reductase B2
NAV2 neuron navigator 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NISCH nischarin
NNMT nicotinamide N-methyltransferase
NOTCH2NL notch 2 N-terminal like
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
PFKP phosphofructokinase, platelet
PHYH phytanoyl-CoA 2-hydroxylase
PLIN3 perilipin 3
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
RAD9A RAD9 homolog A (S. pombe)
RPL36 ribosomal protein L36
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMAD3 SMAD family member 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRPX sushi-repeat containing protein, X-linked
TFF3 trefoil factor 3 (intestinal)
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF185 zinc finger protein 185 (LIM domain)