BRD-K68535470_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K68535470_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD14 CD14 molecule
CD52 CD52 molecule
CLIC3 chloride intracellular channel 3
CNOT4 CCR4-NOT transcription complex, subunit 4
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CRIP2 cysteine-rich protein 2
CTSZ cathepsin Z
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
ELN elastin
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM107A family with sequence similarity 107, member A
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
GLB1L2 galactosidase, beta 1-like 2
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INA internexin neuronal intermediate filament protein, alpha
INTS3 integrator complex subunit 3
ITM2C integral membrane protein 2C
KIAA0753 KIAA0753
KRT19 keratin 19, type I
KRT20 keratin 20, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
MAOA monoamine oxidase A
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
POSTN periostin, osteoblast specific factor
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SCRG1 stimulator of chondrogenesis 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SULF1 sulfatase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TF transferrin
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRAF3IP2 TRAF3 interacting protein 2
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
ZEB1 zinc finger E-box binding homeobox 1
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ARHGAP29 Rho GTPase activating protein 29
ATF1 activating transcription factor 1
ATMIN ATM interactor
BMI1 BMI1 proto-oncogene, polycomb ring finger
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CBFB core-binding factor, beta subunit
CD47 CD47 molecule
CFB complement factor B
CHPT1 choline phosphotransferase 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
E2F2 E2F transcription factor 2
EIF4B eukaryotic translation initiation factor 4B
FAM134B family with sequence similarity 134, member B
FKBP1A FK506 binding protein 1A, 12kDa
G0S2 G0/G1 switch 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMG20B high mobility group 20B
HOXC6 homeobox C6
IL6ST interleukin 6 signal transducer
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LY75 lymphocyte antigen 75
MFSD12 major facilitator superfamily domain containing 12
MRPS30 mitochondrial ribosomal protein S30
NCK2 NCK adaptor protein 2
NEFL neurofilament, light polypeptide
NKTR natural killer cell triggering receptor
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NRIP3 nuclear receptor interacting protein 3
OAT ornithine aminotransferase
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PTGES prostaglandin E synthase
REEP5 receptor accessory protein 5
RNF167 ring finger protein 167
SCML1 sex comb on midleg-like 1 (Drosophila)
SF1 splicing factor 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SNAI2 snail family zinc finger 2
SRSF11 serine/arginine-rich splicing factor 11
TMEM45A transmembrane protein 45A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
UBE3C ubiquitin protein ligase E3C
UFM1 ubiquitin-fold modifier 1
UGCG UDP-glucose ceramide glucosyltransferase
XPO7 exportin 7
YME1L1 YME1-like 1 ATPase