BRD-K68407802_KIN001-055_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K68407802_KIN001-055_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOD apolipoprotein D
BAG2 BCL2-associated athanogene 2
BAX BCL2-associated X protein
BIN1 bridging integrator 1
CHI3L2 chitinase 3-like 2
CHRDL1 chordin-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
GCLC glutamate-cysteine ligase, catalytic subunit
GPER1 G protein-coupled estrogen receptor 1
GPX3 glutathione peroxidase 3
HSPA2 heat shock 70kDa protein 2
LPL lipoprotein lipase
LTBP3 latent transforming growth factor beta binding protein 3
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
MBP myelin basic protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP7 matrix metallopeptidase 7
MOXD1 monooxygenase, DBH-like 1
MSRB1 methionine sulfoxide reductase B1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP210 nucleoporin 210kDa
PENK proenkephalin
SELL selectin L
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SPP1 secreted phosphoprotein 1
SRPX sushi-repeat containing protein, X-linked
TATDN2 TatD DNase domain containing 2
TEX10 testis expressed 10
TGFBR3 transforming growth factor, beta receptor III
TGM2 transglutaminase 2
TIMP4 TIMP metallopeptidase inhibitor 4
TSKU tsukushi, small leucine rich proteoglycan
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ANXA4 annexin A4
ARG2 arginase 2
BGN biglycan
BLNK B-cell linker
C7 complement component 7
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CD24 CD24 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL9 chemokine (C-X-C motif) ligand 9
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HTRA1 HtrA serine peptidase 1
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL1R1 interleukin 1 receptor, type I
KCTD12 potassium channel tetramerization domain containing 12
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS4 lectin, galactoside-binding, soluble, 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
PAPD7 PAP associated domain containing 7
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLS3 plastin 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPRO protein tyrosine phosphatase, receptor type, O
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SEPP1 selenoprotein P, plasma, 1
SMS spermine synthase
SOCS2 suppressor of cytokine signaling 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STAR steroidogenic acute regulatory protein
STS steroid sulfatase (microsomal), isozyme S
THBS1 thrombospondin 1
TM9SF3 transmembrane 9 superfamily member 3
TP53 tumor protein p53
ZNF395 zinc finger protein 395