BRD-K68407802_KIN001-055_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K68407802_KIN001-055_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AFF1 AF4/FMR2 family, member 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
BASP1 brain abundant, membrane attached signal protein 1
CADM1 cell adhesion molecule 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CFI complement factor I
CLEC2B C-type lectin domain family 2, member B
COBL cordon-bleu WH2 repeat protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
FGB fibrinogen beta chain
GABPB1 GA binding protein transcription factor, beta subunit 1
HMG20B high mobility group 20B
IGFBP1 insulin-like growth factor binding protein 1
IGFBP5 insulin-like growth factor binding protein 5
LAPTM4B lysosomal protein transmembrane 4 beta
LOX lysyl oxidase
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MATN2 matrilin 2
MT1E metallothionein 1E
MTUS1 microtubule associated tumor suppressor 1
NES nestin
NMB neuromedin B
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PLA2G16 phospholipase A2, group XVI
PNP purine nucleoside phosphorylase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTRF polymerase I and transcript release factor
SPAG4 sperm associated antigen 4
SUB1 SUB1 homolog (S. cerevisiae)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM140 transmembrane protein 140
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM2 tripartite motif containing 2

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA6 annexin A6
CA1 carbonic anhydrase I
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CST7 cystatin F (leukocystatin)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
ENO1 enolase 1, (alpha)
G0S2 G0/G1 switch 2
GOLGA8A golgin A8 family, member A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IL7R interleukin 7 receptor
KLF6 Kruppel-like factor 6
MME membrane metallo-endopeptidase
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NDRG2 NDRG family member 2
PDIA6 protein disulfide isomerase family A, member 6
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB4 phospholipase C, beta 4
PTPRC protein tyrosine phosphatase, receptor type, C
RPL37A ribosomal protein L37a
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SET SET nuclear proto-oncogene
SLC38A1 solute carrier family 38, member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SQRDL sulfide quinone reductase-like (yeast)
STAR steroidogenic acute regulatory protein
TFRC transferrin receptor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNNT1 troponin T type 1 (skeletal, slow)
VDAC1 voltage-dependent anion channel 1
XIST X inactive specific transcript (non-protein coding)