BRD-K68336408_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K68336408_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
AIM2 absent in melanoma 2
ANXA5 annexin A5
ARF4 ADP-ribosylation factor 4
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BET1 Bet1 golgi vesicular membrane trafficking protein
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNE2 cyclin E2
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
COPA coatomer protein complex, subunit alpha
COPB1 coatomer protein complex, subunit beta 1
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGR1 early growth response 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP1 epithelial membrane protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLT1B golgi transport 1B
GORASP2 golgi reassembly stacking protein 2, 55kDa
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
ICAM3 intercellular adhesion molecule 3
IL6ST interleukin 6 signal transducer
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM4B lysine (K)-specific demethylase 4B
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYDGF myeloid-derived growth factor
MYO10 myosin X
NUCB2 nucleobindin 2
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHGDH phosphoglycerate dehydrogenase
PLTP phospholipid transfer protein
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRBP1 ribosome binding protein 1
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX11 sorting nexin 11
SPRR2B small proline-rich protein 2B
SRP72 signal recognition particle 72kDa
STC2 stanniocalcin 2
SUCO SUN domain containing ossification factor
TARS threonyl-tRNA synthetase
TBL2 transducin (beta)-like 2
TMEM45A transmembrane protein 45A
TRIB3 tribbles pseudokinase 3
TSPAN13 tetraspanin 13
TWF2 twinfilin actin binding protein 2
TXNDC9 thioredoxin domain containing 9
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFM1 ubiquitin-fold modifier 1
VIM vimentin
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CD99 CD99 molecule
CKS2 CDC28 protein kinase regulatory subunit 2
CPE carboxypeptidase E
CRYAB crystallin, alpha B
DMD dystrophin
FAM69A family with sequence similarity 69, member A
GJA1 gap junction protein, alpha 1, 43kDa
H2AFX H2A histone family, member X
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRF8 interferon regulatory factor 8
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
MYBPC1 myosin binding protein C, slow type
P3H2 prolyl 3-hydroxylase 2
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PRKCB protein kinase C, beta
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RANBP1 RAN binding protein 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TARP TCR gamma alternate reading frame protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM1 tropomyosin 1 (alpha)
VCAN versican