BRD-K68191783_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K68191783_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD6 abhydrolase domain containing 6
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BASP1 brain abundant, membrane attached signal protein 1
BRD8 bromodomain containing 8
C1S complement component 1, s subcomponent
CCND2 cyclin D2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CENPU centromere protein U
CGA glycoprotein hormones, alpha polypeptide
CHN1 chimerin 1
CHN2 chimerin 2
COBL cordon-bleu WH2 repeat protein
COL15A1 collagen, type XV, alpha 1
CRYZ crystallin, zeta (quinone reductase)
CTSK cathepsin K
DCK deoxycytidine kinase
FGFR3 fibroblast growth factor receptor 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FMR1 fragile X mental retardation 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMGB3 high mobility group box 3
HSPA2 heat shock 70kDa protein 2
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIAA1109 KIAA1109
KIF20A kinesin family member 20A
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
LYST lysosomal trafficking regulator
MAP7 microtubule-associated protein 7
MELK maternal embryonic leucine zipper kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MYO6 myosin VI
NDP Norrie disease (pseudoglioma)
NPY neuropeptide Y
OPN3 opsin 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAM peptidylglycine alpha-amidating monooxygenase
PHYH phytanoyl-CoA 2-hydroxylase
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNISR PNN-interacting serine/arginine-rich protein
PRAME preferentially expressed antigen in melanoma
PSIP1 PC4 and SFRS1 interacting protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
RSRP1 arginine/serine-rich protein 1
RUFY3 RUN and FYVE domain containing 3
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SATB2 SATB homeobox 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STAT1 signal transducer and activator of transcription 1, 91kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFF3 trefoil factor 3 (intestinal)
TPD52L1 tumor protein D52-like 1
TPPP3 tubulin polymerization-promoting protein family member 3
TSPAN7 tetraspanin 7
TTC17 tetratricopeptide repeat domain 17
TUSC3 tumor suppressor candidate 3
TWF1 twinfilin actin binding protein 1
UBE2A ubiquitin-conjugating enzyme E2A
VIM vimentin
WIPF1 WAS/WASL interacting protein family, member 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADRM1 adhesion regulating molecule 1
AKAP12 A kinase (PRKA) anchor protein 12
AKIRIN1 akirin 1
ALDOA aldolase A, fructose-bisphosphate
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BAX BCL2-associated X protein
BCL6 B-cell CLL/lymphoma 6
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CCDC85B coiled-coil domain containing 85B
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A1 collagen, type I, alpha 1
CRIP2 cysteine-rich protein 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSK c-src tyrosine kinase
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTSD cathepsin D
CXCL8 chemokine (C-X-C motif) ligand 8
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF4B eukaryotic translation initiation factor 4B
FASN fatty acid synthase
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FPGS folylpolyglutamate synthase
FUS FUS RNA binding protein
GRWD1 glutamate-rich WD repeat containing 1
HBEGF heparin-binding EGF-like growth factor
HSPB1 heat shock 27kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
LOX lysyl oxidase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTBP3 latent transforming growth factor beta binding protein 3
LYZ lysozyme
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
PDAP1 PDGFA associated protein 1
PDIA3 protein disulfide isomerase family A, member 3
PECAM1 platelet/endothelial cell adhesion molecule 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PRPF19 pre-mRNA processing factor 19
PRR7 proline rich 7 (synaptic)
PUF60 poly-U binding splicing factor 60KDa
RBP4 retinol binding protein 4, plasma
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNH1 ribonuclease/angiogenin inhibitor 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SF1 splicing factor 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SRSF6 serine/arginine-rich splicing factor 6
STIP1 stress-induced phosphoprotein 1
TEAD4 TEA domain family member 4
TGOLN2 trans-golgi network protein 2
THBS1 thrombospondin 1
TPM4 tropomyosin 4
UBE2G2 ubiquitin-conjugating enzyme E2G 2
VCAN versican
ZFP36L2 ZFP36 ring finger protein-like 2
ZMAT3 zinc finger, matrin-type 3
ZYX zyxin