BRD-K68174511_torin-2_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K68174511_torin-2_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARID5B AT rich interactive domain 5B (MRF1-like)
AUTS2 autism susceptibility candidate 2
BAMBI BMP and activin membrane-bound inhibitor
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CCNG1 cyclin G1
CCNG2 cyclin G2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPE centromere protein E, 312kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EDN1 endothelin 1
ELOVL2 ELOVL fatty acid elongase 2
EMP2 epithelial membrane protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAS Fas cell surface death receptor
GRB7 growth factor receptor-bound protein 7
GSTM3 glutathione S-transferase mu 3 (brain)
HBP1 HMG-box transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IL6ST interleukin 6 signal transducer
IRS1 insulin receptor substrate 1
KAT6B K(lysine) acetyltransferase 6B
KDM3A lysine (K)-specific demethylase 3A
KIAA0355 KIAA0355
KIF20A kinesin family member 20A
LPIN2 lipin 2
LXN latexin
MARCKSL1 MARCKS-like 1
MBNL2 muscleblind-like splicing regulator 2
MLPH melanophilin
NAV3 neuron navigator 3
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
OLFML3 olfactomedin-like 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PTX3 pentraxin 3, long
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFRP1 secreted frizzled-related protein 1
SKAP2 src kinase associated phosphoprotein 2
SRPX sushi-repeat containing protein, X-linked
TBC1D4 TBC1 domain family, member 4
TFPI2 tissue factor pathway inhibitor 2
TGIF1 TGFB-induced factor homeobox 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
UGCG UDP-glucose ceramide glucosyltransferase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ADIRF adipogenesis regulatory factor
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFB complement factor B
CKAP4 cytoskeleton-associated protein 4
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DUOX2 dual oxidase 2
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GAL galanin/GMAP prepropeptide
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPX1 glutathione peroxidase 1
GREM1 gremlin 1, DAN family BMP antagonist
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
ISG15 ISG15 ubiquitin-like modifier
KDM5D lysine (K)-specific demethylase 5D
KRT17 keratin 17, type I
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
PEA15 phosphoprotein enriched in astrocytes 15
PODXL podocalyxin-like
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRSS2 protease, serine, 2 (trypsin 2)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM15B RNA binding motif protein 15B
REG1A regenerating islet-derived 1 alpha
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SUB1 SUB1 homolog (S. cerevisiae)
WBP5 WW domain binding protein 5