BRD-K68174511_torin-2_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

293 genes differentially expressed following the BRD-K68174511_torin-2_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD11 abhydrolase domain containing 11
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADAM12 ADAM metallopeptidase domain 12
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
AKAP9 A kinase (PRKA) anchor protein 9
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKRD36B ankyrin repeat domain 36B
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
BACE2 beta-site APP-cleaving enzyme 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CCNG1 cyclin G1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN4 claudin 4
CLIC5 chloride intracellular channel 5
COBL cordon-bleu WH2 repeat protein
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CST1 cystatin SN
CTSL cathepsin L
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DYNLT3 dynein, light chain, Tctex-type 3
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB3 erb-b2 receptor tyrosine kinase 3
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM102A family with sequence similarity 102, member A
FAS Fas cell surface death receptor
FAXDC2 fatty acid hydroxylase domain containing 2
FKBP14 FK506 binding protein 14, 22 kDa
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GATAD1 GATA zinc finger domain containing 1
GCC2 GRIP and coiled-coil domain containing 2
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB10 growth factor receptor-bound protein 10
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HNMT histamine N-methyltransferase
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0907 KIAA0907
KIAA1033 KIAA1033
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LEFTY1 left-right determination factor 1
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LONP2 lon peptidase 2, peroxisomal
LOX lysyl oxidase
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MLPH melanophilin
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NCK2 NCK adaptor protein 2
NCOA3 nuclear receptor coactivator 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMRK1 nicotinamide riboside kinase 1
NT5C2 5'-nucleotidase, cytosolic II
NUCB2 nucleobindin 2
OFD1 oral-facial-digital syndrome 1
OPN3 opsin 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCCA propionyl CoA carboxylase, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRSS8 protease, serine, 8
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
RAB9A RAB9A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RPL36 ribosomal protein L36
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCYL3 SCY1-like 3 (S. cerevisiae)
SECISBP2L SECIS binding protein 2-like
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SPDEF SAM pointed domain containing ETS transcription factor
SQSTM1 sequestosome 1
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
STAR steroidogenic acute regulatory protein
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STXBP2 syntaxin binding protein 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D15 TBC1 domain family, member 15
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM63A transmembrane protein 63A
TOB1 transducer of ERBB2, 1
TOM1L1 target of myb1 (chicken)-like 1
TRAF5 TNF receptor-associated factor 5
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TTC17 tetratricopeptide repeat domain 17
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF277 zinc finger protein 277
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BARD1 BRCA1 associated RING domain 1
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CKS2 CDC28 protein kinase regulatory subunit 2
CORO1A coronin, actin binding protein, 1A
CTPS1 CTP synthase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO1 enolase 1, (alpha)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
FGL2 fibrinogen-like 2
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAGE3 L antigen family, member 3
LBR lamin B receptor
LMNB1 lamin B1
LMO3 LIM domain only 3 (rhombotin-like 2)
LMO4 LIM domain only 4
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAM1 neural cell adhesion molecule 1
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NELL2 NEL-like 2 (chicken)
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCP4 Purkinje cell protein 4
PDE8B phosphodiesterase 8B
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKCB protein kinase C, beta
PRMT1 protein arginine methyltransferase 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RCAN2 regulator of calcineurin 2
RFC3 replication factor C (activator 1) 3, 38kDa
RGS5 regulator of G-protein signaling 5
RIMS3 regulating synaptic membrane exocytosis 3
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLBP stem-loop binding protein
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SRM spermidine synthase
STMN1 stathmin 1
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCF4 transcription factor 4
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZWINT ZW10 interacting kinetochore protein